abnormal lean body mass Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the amount of the fat-free physical bulk or volume of the body including all its components except adipose tissue (Mammalian Phenotype Ontology, MP_0003959)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003959
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Genes

181 gene mutations causing the abnormal lean body mass phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
ACOT11 acyl-CoA thioesterase 11
ACOT13 acyl-CoA thioesterase 13
ACSL3 acyl-CoA synthetase long-chain family member 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIPOR2 adiponectin receptor 2
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGRP agouti related neuropeptide
AHCYL1 adenosylhomocysteinase-like 1
AKAP9 A kinase (PRKA) anchor protein 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANKRD26 ankyrin repeat domain 26
ARL4D ADP-ribosylation factor-like 4D
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
B9D1 B9 protein domain 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BBS5 Bardet-Biedl syndrome 5
BBX bobby sox homolog (Drosophila)
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BRPF1 bromodomain and PHD finger containing, 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C3AR1 complement component 3a receptor 1
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CD14 CD14 molecule
CD200 CD200 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CENPJ centromere protein J
CHD7 chromodomain helicase DNA binding protein 7
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CISD2 CDGSH iron sulfur domain 2
CLSTN3 calsyntenin 3
CNIH1 cornichon family AMPA receptor auxiliary protein 1
COL1A1 collagen, type I, alpha 1
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung)
CRH corticotropin releasing hormone
CRLF3 cytokine receptor-like factor 3
CSRP2BP CSRP2 binding protein
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CUL7 cullin 7
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DAAM2 dishevelled associated activator of morphogenesis 2
DDR2 discoidin domain receptor tyrosine kinase 2
DEGS1 delta(4)-desaturase, sphingolipid 1
DLL1 delta-like 1 (Drosophila)
DMXL2 Dmx-like 2
DNASE1L2 deoxyribonuclease I-like 2
DUSP3 dual specificity phosphatase 3
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELMOD1 ELMO/CED-12 domain containing 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERP44 endoplasmic reticulum protein 44
ESRRA estrogen-related receptor alpha
FAM117B family with sequence similarity 117, member B
FAM134C family with sequence similarity 134, member C
FAM73B family with sequence similarity 73, member B
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FBXO11 F-box protein 11
FGF21 fibroblast growth factor 21
FOXP2 forkhead box P2
FTO fat mass and obesity associated
GDF15 growth differentiation factor 15
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GLP1R glucagon-like peptide 1 receptor
GNAS GNAS complex locus
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPR21 G protein-coupled receptor 21
GPR22 G protein-coupled receptor 22
GPR39 G protein-coupled receptor 39
GPRC6A G protein-coupled receptor, class C, group 6, member A
GRB10 growth factor receptor-bound protein 10
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSK3A glycogen synthase kinase 3 alpha
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL1R1 interleukin 1 receptor, type I
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA1549L KIAA1549-like
KLF15 Kruppel-like factor 15
L3MBTL2 l(3)mbt-like 2 (Drosophila)
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LPIN1 lipin 1
MARC2 mitochondrial amidoxime reducing component 2
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
MECOM MDS1 and EVI1 complex locus
METTL24 methyltransferase like 24
MFSD2A major facilitator superfamily domain containing 2A
MRAP2 melanocortin 2 receptor accessory protein 2
MSTN myostatin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXRA7 matrix-remodelling associated 7
MYBPC3 myosin binding protein C, cardiac
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NEGR1 neuronal growth regulator 1
NMUR2 neuromedin U receptor 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPTN neuroplastin
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NXN nucleoredoxin
OPRM1 opioid receptor, mu 1
OSTM1 osteopetrosis associated transmembrane protein 1
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PACS2 phosphofurin acidic cluster sorting protein 2
PBX3 pre-B-cell leukemia homeobox 3
PCNA proliferating cell nuclear antigen
PDE10A phosphodiesterase 10A
PDYN prodynorphin
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PITX3 paired-like homeodomain 3
PLIN1 perilipin 1
PNLIP pancreatic lipase
POMC proopiomelanocortin
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTRF polymerase I and transcript release factor
PYY peptide YY
RBMX RNA binding motif protein, X-linked
ROR2 receptor tyrosine kinase-like orphan receptor 2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SCP2 sterol carrier protein 2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SELK selenoprotein K
SERF1A small EDRK-rich factor 1A (telomeric)
SERINC1 serine incorporator 1
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP5 secreted frizzled-related protein 5
SH3KBP1 SH3-domain kinase binding protein 1
SIRT2 sirtuin 2
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC38A10 solute carrier family 38, member 10
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SMCO2 single-pass membrane protein with coiled-coil domains 2
SMS spermine synthase
SNAP47 synaptosomal-associated protein, 47kDa
SNIP1 Smad nuclear interacting protein 1
SPP1 secreted phosphoprotein 1
SPPL3 signal peptide peptidase like 3
STRA6 stimulated by retinoic acid 6
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D2B TBC1 domain family, member 2B
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM189 transmembrane protein 189
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNIK TRAF2 and NCK interacting kinase
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TSN translin
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL4 tubulin tyrosine ligase-like family member 4
UBE3B ubiquitin protein ligase E3B
UMOD uromodulin
USH1C Usher syndrome 1C (autosomal recessive, severe)
USP24 ubiquitin specific peptidase 24
USP38 ubiquitin specific peptidase 38
VGF VGF nerve growth factor inducible
VIPR2 vasoactive intestinal peptide receptor 2
XYLB xylulokinase homolog (H. influenzae)
ZC3HC1 zinc finger, C3HC-type containing 1