abnormal lacrimal gland development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant formation or incomplete differentiation of the paired almond-shaped glands, one for each eye, that secrete the aqueous layer of the tear film; each lacrimal gland develops through branching morphogenesis regulated by FGF signaling; at E12.5, the conjunctival epithelium at the temporal side of the mouse eyes invades the Fgf10-expressing mesenchyme to form the initial lacrimal gland bud; the bud elongates posteriorly until E15.5 when secondary branching begins to establish the complex tubuloalveolar structure; this eventually gives rise to the mature lacrimal gland composed of numerous ducts, acini and connective tissue (Mammalian Phenotype Ontology, MP_0013331)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0013331
Similar Terms
Downloads & Tools

Genes

2 gene mutations causing the abnormal lacrimal gland development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
FOXC1 forkhead box C1
SIX1 SIX homeobox 1