abnormal interleukin-6 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts (Mammalian Phenotype Ontology, MP_0008704)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008704
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Genes

139 gene mutations causing the abnormal interleukin-6 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACP1 acid phosphatase 1, soluble
ADORA2B adenosine A2b receptor
AIRE autoimmune regulator
APOE apolipoprotein E
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATG9A autophagy related 9A
AZI2 5-azacytidine induced 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAG4 BCL2-associated athanogene 4
CARD9 caspase recruitment domain family, member 9
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CC2D1A coiled-coil and C2 domain containing 1A
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD200R1 CD200 receptor 1
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC6A C-type lectin domain family 6, member A
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
CORO1A coronin, actin binding protein, 1A
CXCL6 chemokine (C-X-C motif) ligand 6
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DMD dystrophin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
F3 coagulation factor III (thromboplastin, tissue factor)
FASTK Fas-activated serine/threonine kinase
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCMR Fc fragment of IgM receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GRN granulin
HSPA1B heat shock 70kDa protein 1B
HSPB1 heat shock 27kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IDO2 indoleamine 2,3-dioxygenase 2
IFIH1 interferon induced with helicase C domain 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNGR1 interferon gamma receptor 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL12RB2 interleukin 12 receptor, beta 2
IL17RA interleukin 17 receptor A
IL17RB interleukin 17 receptor B
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RAP interleukin 1 receptor accessory protein
IL33 interleukin 33
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ING4 inhibitor of growth family, member 4
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF5 interferon regulatory factor 5
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGMN legumain
LY96 lymphocyte antigen 96
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAVS mitochondrial antiviral signaling protein
MBTPS1 membrane-bound transcription factor peptidase, site 1
MMP28 matrix metallopeptidase 28
MOG myelin oligodendrocyte glycoprotein
MYD88 myeloid differentiation primary response 88
NAMPT nicotinamide phosphoribosyltransferase
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NLRC5 NLR family, CARD domain containing 5
NLRX1 NLR family member X1
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PBK PDZ binding kinase
PELI1 pellino E3 ubiquitin protein ligase 1
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G2D phospholipase A2, group IID
POMC proopiomelanocortin
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKCD protein kinase C, delta
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RHBDD3 rhomboid domain containing 3
RIPK2 receptor-interacting serine-threonine kinase 2
SELK selenoprotein K
SH2D3C SH2 domain containing 3C
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SQSTM1 sequestosome 1
STIM1 stromal interaction molecule 1
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR8 toll-like receptor 8
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIP1 TNFAIP3 interacting protein 1
TOLLIP toll interacting protein
TRADD TNFRSF1A-associated via death domain
TRAF3IP2 TRAF3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAFD1 TRAF-type zinc finger domain containing 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
USP18 ubiquitin specific peptidase 18
USP25 ubiquitin specific peptidase 25
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H12D zinc finger CCCH-type containing 12D