abnormal interleukin-4 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells (Mammalian Phenotype Ontology, MP_0008698)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008698
Similar Terms
Downloads & Tools

Genes

104 gene mutations causing the abnormal interleukin-4 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHNAK AHNAK nucleoprotein
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATF3 activating transcription factor 3
B2M beta-2-microglobulin
BATF basic leucine zipper transcription factor, ATF-like
BHLHE41 basic helix-loop-helix family, member e41
C3AR1 complement component 3a receptor 1
CADM1 cell adhesion molecule 1
CCL13 chemokine (C-C motif) ligand 13
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCRL2 chemokine (C-C motif) receptor-like 2
CD1D CD1d molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD300LF CD300 molecule-like family member f
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CISH cytokine inducible SH2-containing protein
CLEC10A C-type lectin domain family 10, member A
CLNK cytokine-dependent hematopoietic cell linker
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSE cathepsin E
CXCL16 chemokine (C-X-C motif) ligand 16
DMD dystrophin
DTX1 deltex 1, E3 ubiquitin ligase
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
EBI3 Epstein-Barr virus induced 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
FLG filaggrin
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GPR34 G protein-coupled receptor 34
GPR84 G protein-coupled receptor 84
HAVCR1 hepatitis A virus cellular receptor 1
HCST hematopoietic cell signal transducer
HRH1 histamine receptor H1
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IL13 interleukin 13
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL1RL1 interleukin 1 receptor-like 1
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL25 interleukin 25
IL27RA interleukin 27 receptor, alpha
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ITK IL2-inducible T-cell kinase
LAT linker for activation of T cells
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MARK2 MAP/microtubule affinity-regulating kinase 2
MBP myelin basic protein
MEFV Mediterranean fever
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR155 microRNA 155
MMP9 matrix metallopeptidase 9
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
ORAI1 ORAI calcium release-activated calcium modulator 1
POU2AF1 POU class 2 associating factor 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCQ protein kinase C, theta
RAD50 RAD50 homolog (S. cerevisiae)
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RFTN1 raftlin, lipid raft linker 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RSAD2 radical S-adenosyl methionine domain containing 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SASH3 SAM and SH3 domain containing 3
SH2D2A SH2 domain containing 2A
SIRT7 sirtuin 7
SLAMF6 SLAM family member 6
SPP1 secreted phosphoprotein 1
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
VAV1 vav 1 guanine nucleotide exchange factor
VIPR2 vasoactive intestinal peptide receptor 2
VTCN1 V-set domain containing T cell activation inhibitor 1