abnormal interleukin-2 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes (Mammalian Phenotype Ontology, MP_0008686)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008686
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Genes

97 gene mutations causing the abnormal interleukin-2 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHNAK AHNAK nucleoprotein
AIRE autoimmune regulator
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BCL2L1 BCL2-like 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BTLA B and T lymphocyte associated
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CADM1 cell adhesion molecule 1
CARD11 caspase recruitment domain family, member 11
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CD1D CD1d molecule
CD28 CD28 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CORO1A coronin, actin binding protein, 1A
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DBNL drebrin-like
DGKA diacylglycerol kinase, alpha 80kDa
DGKZ diacylglycerol kinase, zeta
DMD dystrophin
DTX1 deltex 1, E3 ubiquitin ligase
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FPR2 formyl peptide receptor 2
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR34 G protein-coupled receptor 34
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HRH1 histamine receptor H1
HSH2D hematopoietic SH2 domain containing
IFNG interferon, gamma
IL12B interleukin 12B
IL15RA interleukin 15 receptor, alpha
IL1B interleukin 1, beta
IL20RB interleukin 20 receptor beta
IL2RG interleukin 2 receptor, gamma
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITK IL2-inducible T-cell kinase
LAPTM5 lysosomal protein transmembrane 5
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS1 lectin, galactoside-binding, soluble, 1
MALT1 MALT1 paracaspase
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MBP myelin basic protein
MEFV Mediterranean fever
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MMP1 matrix metallopeptidase 1
MOG myelin oligodendrocyte glycoprotein
NDFIP1 Nedd4 family interacting protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NME2 NME/NM23 nucleoside diphosphate kinase 2
ORAI1 ORAI calcium release-activated calcium modulator 1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAP1A RAP1A, member of RAS oncogene family
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SASH3 SAM and SH3 domain containing 3
SH2D2A SH2 domain containing 2A
SIT1 signaling threshold regulating transmembrane adaptor 1
SKAP1 src kinase associated phosphoprotein 1
SOCS3 suppressor of cytokine signaling 3
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
SUCNR1 succinate receptor 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TESPA1 thymocyte expressed, positive selection associated 1
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
VAV1 vav 1 guanine nucleotide exchange factor
VIPR2 vasoactive intestinal peptide receptor 2
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa