abnormal interferon-gamma secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation (Mammalian Phenotype Ontology, MP_0008559)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008559
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Genes

218 gene mutations causing the abnormal interferon-gamma secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHNAK AHNAK nucleoprotein
AIM2 absent in melanoma 2
APOE apolipoprotein E
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTLA B and T lymphocyte associated
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CADM1 cell adhesion molecule 1
CARD11 caspase recruitment domain family, member 11
CASP12 caspase 12 (gene/pseudogene)
CCL13 chemokine (C-C motif) ligand 13
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD19 CD19 molecule
CD1D CD1d molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD69 CD69 molecule
CD7 CD7 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD86 CD86 molecule
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC4F C-type lectin domain family 4, member F
CLEC6A C-type lectin domain family 6, member A
CLNK cytokine-dependent hematopoietic cell linker
COMT catechol-O-methyltransferase
CRTAM cytotoxic and regulatory T cell molecule
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL16 chemokine (C-X-C motif) ligand 16
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DMD dystrophin
DTX1 deltex 1, E3 ubiquitin ligase
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
EBI3 Epstein-Barr virus induced 3
EFS embryonal Fyn-associated substrate
ERAP1 endoplasmic reticulum aminopeptidase 1
FADS1 fatty acid desaturase 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGR FGR proto-oncogene, Src family tyrosine kinase
FLG filaggrin
FLT3 fms-related tyrosine kinase 3
FOXN1 forkhead box N1
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PC2 glucose-6-phosphatase, catalytic, 2
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GATA3 GATA binding protein 3
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR15 G protein-coupled receptor 15
GPR34 G protein-coupled receptor 34
HAVCR2 hepatitis A virus cellular receptor 2
HCST hematopoietic cell signal transducer
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-G major histocompatibility complex, class I, G
HRH1 histamine receptor H1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IDO1 indoleamine 2,3-dioxygenase 1
IDO2 indoleamine 2,3-dioxygenase 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL10RB interleukin 10 receptor, beta
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL17A interleukin 17A
IL17C interleukin 17C
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1B interleukin 1, beta
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL27 interleukin 27
IL27RA interleukin 27 receptor, alpha
IL2RG interleukin 2 receptor, gamma
IL34 interleukin 34
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
JAK3 Janus kinase 3
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS1 lectin, galactoside-binding, soluble, 1
LIG4 ligase IV, DNA, ATP-dependent
LTA lymphotoxin alpha
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCO macrophage receptor with collagenous structure
MARK2 MAP/microtubule affinity-regulating kinase 2
MBP myelin basic protein
MEFV Mediterranean fever
MIR155 microRNA 155
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
MUC2 mucin 2, oligomeric mucus/gel-forming
MYD88 myeloid differentiation primary response 88
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFIL3 nuclear factor, interleukin 3 regulated
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NLRP10 NLR family, pyrin domain containing 10
NLRP3 NLR family, pyrin domain containing 3
NME2 NME/NM23 nucleoside diphosphate kinase 2
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
ORAI1 ORAI calcium release-activated calcium modulator 1
PDCD1LG2 programmed cell death 1 ligand 2
PDLIM2 PDZ and LIM domain 2 (mystique)
PECAM1 platelet/endothelial cell adhesion molecule 1
PIGR polymeric immunoglobulin receptor
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRF1 perforin 1 (pore forming protein)
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYCARD PYD and CARD domain containing
RCAN1 regulator of calcineurin 1
RETNLB resistin like beta
RFTN1 raftlin, lipid raft linker 1
RHBDD3 rhomboid domain containing 3
RIPK2 receptor-interacting serine-threonine kinase 2
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RSAD2 radical S-adenosyl methionine domain containing 2
SASH3 SAM and SH3 domain containing 3
SH2D1A SH2 domain containing 1A
SH2D1B SH2 domain containing 1B
SH2D2A SH2 domain containing 2A
SIT1 signaling threshold regulating transmembrane adaptor 1
SKAP1 src kinase associated phosphoprotein 1
SOCS2 suppressor of cytokine signaling 2
SPP1 secreted phosphoprotein 1
SSTR4 somatostatin receptor 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
STX11 syntaxin 11
TBX21 T-box 21
TESPA1 thymocyte expressed, positive selection associated 1
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM27 tripartite motif containing 27
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSC22D3 TSC22 domain family, member 3
TSLP thymic stromal lymphopoietin
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
USP18 ubiquitin specific peptidase 18
USP25 ubiquitin specific peptidase 25
VAV1 vav 1 guanine nucleotide exchange factor
VIPR2 vasoactive intestinal peptide receptor 2
VTCN1 V-set domain containing T cell activation inhibitor 1
XCR1 chemokine (C motif) receptor 1
ZBTB7B zinc finger and BTB domain containing 7B
ZC3H12A zinc finger CCCH-type containing 12A