abnormal induced cell death Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the response to an agent that induces cessation of function at the cellular level (Mammalian Phenotype Ontology, MP_0008942)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008942
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Genes

189 gene mutations causing the abnormal induced cell death phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHSP alpha hemoglobin stabilizing protein
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANTXR1 anthrax toxin receptor 1
ANTXR2 anthrax toxin receptor 2
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ATF6 activating transcription factor 6
ATF6B activating transcription factor 6 beta
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATR ATR serine/threonine kinase
BAD BCL2-associated agonist of cell death
BBC3 BCL2 binding component 3
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CASP12 caspase 12 (gene/pseudogene)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CC2D1A coiled-coil and C2 domain containing 1A
CCNG1 cyclin G1
CCS copper chaperone for superoxide dismutase
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHD2 chromodomain helicase DNA binding protein 2
CHEK2 checkpoint kinase 2
CLP1 cleavage and polyadenylation factor I subunit 1
COPS6 COP9 signalosome subunit 6
CP ceruloplasmin (ferroxidase)
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CREBBP CREB binding protein
CRYBB2 crystallin, beta B2
CTH cystathionine gamma-lyase
CUL4A cullin 4A
CUL9 cullin 9
CYCS cytochrome c, somatic
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DCLRE1C DNA cross-link repair 1C
DDB2 damage-specific DNA binding protein 2, 48kDa
DPH1 diphthamide biosynthesis 1
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF2 eukaryotic translation elongation factor 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL1 ELAV like RNA binding protein 1
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
ERO1L ERO1-like (S. cerevisiae)
FAF1 Fas (TNFRSF6) associated factor 1
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FEN1 flap structure-specific endonuclease 1
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GPX1 glutathione peroxidase 1
GPX7 glutathione peroxidase 7
HELLS helicase, lymphoid-specific
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HINT1 histidine triad nucleotide binding protein 1
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HIST1H1C histone cluster 1, H1c
HMGN1 high mobility group nucleosome binding domain 1
IFT122 intraflagellar transport 122
ING1 inhibitor of growth family, member 1
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein
IVNS1ABP influenza virus NS1A binding protein
JUN jun proto-oncogene
JUND jun D proto-oncogene
LIG4 ligase IV, DNA, ATP-dependent
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPKAP1 mitogen-activated protein kinase associated protein 1
MBD4 methyl-CpG binding domain protein 4
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MIR144 microRNA 144
MIR451A microRNA 451a
MLH1 mutL homolog 1
MLKL mixed lineage kinase domain-like
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTA1 metastasis associated 1
MTF1 metal-regulatory transcription factor 1
MTFR1 mitochondrial fission regulator 1
MUS81 MUS81 structure-specific endonuclease subunit
MXD3 MAX dimerization protein 3
NBN nibrin
NDRG1 N-myc downstream regulated 1
NFE2L2 nuclear factor, erythroid 2-like 2
NHEJ1 nonhomologous end-joining factor 1
NINJ1 ninjurin 1
NIT1 nitrilase 1
NOA1 nitric oxide associated 1
OMA1 OMA1 zinc metallopeptidase
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP14 poly (ADP-ribose) polymerase family, member 14
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PER2 period circadian clock 2
PERP PERP, TP53 apoptosis effector
PINK1 PTEN induced putative kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
POLK polymerase (DNA directed) kappa
PPIF peptidylprolyl isomerase F
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51D RAD51 paralog D
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RAD9B RAD9 homolog B (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
REG1B regenerating islet-derived 1 beta
RGN regucalcin
RIF1 replication timing regulatory factor 1
RIPK3 receptor-interacting serine-threonine kinase 3
RIT1 Ras-like without CAAX 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF7 ring finger protein 7
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SESN2 sestrin 2
SETD7 SET domain containing (lysine methyltransferase) 7
SGOL1 shugoshin-like 1 (S. pombe)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SIRT6 sirtuin 6
SIRT7 sirtuin 7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
SLX4 SLX4 structure-specific endonuclease subunit
SMC1A structural maintenance of chromosomes 1A
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC2 stanniocalcin 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TPT1 tumor protein, translationally-controlled 1
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRIM27 tripartite motif containing 27
TRIP12 thyroid hormone receptor interactor 12
TROVE2 TROVE domain family, member 2
TYR tyrosinase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UIMC1 ubiquitin interaction motif containing 1
UNG uracil-DNA glycosylase
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP47 ubiquitin specific peptidase 47
VASN vasorin
WRN Werner syndrome, RecQ helicase-like
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZFP36 ZFP36 ring finger protein