abnormal immunoglobulin level Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormal deviation from normal levels of immunoglobulins in blood. (Human Phenotype Ontology, HP_0010701)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0010701
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Genes

344 genes associated with the abnormal immunoglobulin level phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 2.83286
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.30755
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.12053
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 2.09607
IL13 interleukin 13 1.87544
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.82094
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 1.5645
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.54733
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 1.48419
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 1.47083
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 1.41863
IFIH1 interferon induced with helicase C domain 1 1.36794
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) 1.35901
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 1.29386
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.26545
LAMB1 laminin, beta 1 1.24751
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.21853
SLC38A10 solute carrier family 38, member 10 1.19958
RAD50 RAD50 homolog (S. cerevisiae) 1.18704
RECK reversion-inducing-cysteine-rich protein with kazal motifs 1.18704
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 1.1784
IL4R interleukin 4 receptor 1.15352
SEPHS1 selenophosphate synthetase 1 1.15352
FXR2 fragile X mental retardation, autosomal homolog 2 1.12851
LINC00299 long intergenic non-protein coding RNA 299 1.12851
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 1.12851
CLEC16A C-type lectin domain family 16, member A 1.12851
SNORD48 small nucleolar RNA, C/D box 48 1.11203
MX1 MX dynamin-like GTPase 1 1.11203
RYR2 ryanodine receptor 2 (cardiac) 1.11203
LRRTM4 leucine rich repeat transmembrane neuronal 4 1.09906
CEP131 centrosomal protein 131kDa 1.09906
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.09906
EGF epidermal growth factor 1.09906
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.09906
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 1.09906
FOXP2 forkhead box P2 1.08774
SNTG1 syntrophin, gamma 1 1.07729
ARMC3 armadillo repeat containing 3 1.07729
RELL1 RELT-like 1 1.07729
HLA-A major histocompatibility complex, class I, A 1.07617
LRP1 low density lipoprotein receptor-related protein 1 1.07193
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 1.0674
CLRN1-AS1 CLRN1 antisense RNA 1 1.0674
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.06531
AAA1 aortic aneurysm, familial abdominal 1 1.05869
ZBTB39 zinc finger and BTB domain containing 39 1.05616
IL2 interleukin 2 1.04365
TRIM5 tripartite motif containing 5 1.04365
ITGA11 integrin, alpha 11 1.04365
EPAS1 endothelial PAS domain protein 1 1.04365
KCNIP4 Kv channel interacting protein 4 1.04365
VAV2 vav 2 guanine nucleotide exchange factor 1.04365
SGCZ sarcoglycan, zeta 1.04365
STAB2 stabilin 2 1.04365
WWP2 WW domain containing E3 ubiquitin protein ligase 2 1.04365
ARID5B AT rich interactive domain 5B (MRF1-like) 1.04365
ELL2 elongation factor, RNA polymerase II, 2 1.04365
TMEM132D transmembrane protein 132D 1.00059
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 1.00059
SLIT1 slit homolog 1 (Drosophila) 1.00059
COL19A1 collagen, type XIX, alpha 1 1.00059
DGKZ diacylglycerol kinase, zeta 1.00059
GLI3 GLI family zinc finger 3 1.00059
LPP LIM domain containing preferred translocation partner in lipoma 1.00059
CPNE8 copine VIII 1.00059
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.00059
SHISA6 shisa family member 6 1.00059
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 1.00059
EPS15 epidermal growth factor receptor pathway substrate 15 1.00059
LOC286190 1.00059
SMYD2 SET and MYND domain containing 2 1.00059
SBF1 SET binding factor 1 1.00059
SMYD1 SET and MYND domain containing 1 1.00059
LOC729911 1.00059
EPB41L2 erythrocyte membrane protein band 4.1-like 2 1.00059
CCDC40 coiled-coil domain containing 40 1.00059
PARVB parvin, beta 1.00059
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.998051
COL26A1 collagen, type XXVI, alpha 1 0.982079
TRIM6 tripartite motif containing 6 0.969142
CTIF CBP80/20-dependent translation initiation factor 0.969142
DNAH5 dynein, axonemal, heavy chain 5 0.969142
CNTNAP5 contactin associated protein-like 5 0.969142
EYS eyes shut homolog (Drosophila) 0.969142
POU6F2 POU class 6 homeobox 2 0.969142
PRKG1 protein kinase, cGMP-dependent, type I 0.969142
PTPRT protein tyrosine phosphatase, receptor type, T 0.969142
SKI SKI proto-oncogene 0.969142
MDC1 mediator of DNA-damage checkpoint 1 0.969142
SORBS1 sorbin and SH3 domain containing 1 0.969142
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 0.969142
LINC00469 long intergenic non-protein coding RNA 469 0.969142
ANGPT1 angiopoietin 1 0.969142
NCK2 NCK adaptor protein 2 0.964823
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 0.942765
GFRA1 GDNF family receptor alpha 1 0.942765
ELMO1 engulfment and cell motility 1 0.942765
LINGO2 leucine rich repeat and Ig domain containing 2 0.942765
REC114 REC114 meiotic recombination protein 0.942765
ZNF423 zinc finger protein 423 0.942765
CDK18 cyclin-dependent kinase 18 0.942765
LBR lamin B receptor 0.942765
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.942765
LOC100505940 0.942765
NRG3 neuregulin 3 0.942765
CHD2 chromodomain helicase DNA binding protein 2 0.942765
ABI3 ABI family, member 3 0.942765
PLD5 phospholipase D family, member 5 0.942765
ETV6 ets variant 6 0.942765
AGR2 anterior gradient 2 0.942765
JAKMIP1 janus kinase and microtubule interacting protein 1 0.942765
TOPAZ1 testis and ovary specific PAZ domain containing 1 0.942765
AUTS2 autism susceptibility candidate 2 0.942765
CDH13 cadherin 13 0.942765
NFASC neurofascin 0.931243
LRRC4C leucine rich repeat containing 4C 0.919744
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.919744
FRY furry homolog (Drosophila) 0.919744
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.919744
CNTN1 contactin 1 0.919744
LBP lipopolysaccharide binding protein 0.919744
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.919744
ANO2 anoctamin 2, calcium activated chloride channel 0.919744
PARK2 parkin RBR E3 ubiquitin protein ligase 0.919744
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.919744
CSMD1 CUB and Sushi multiple domains 1 0.919744
ZNF804B zinc finger protein 804B 0.919744
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.919744
ACO1 aconitase 1, soluble 0.919744
FMNL2 formin-like 2 0.919744
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.919744
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.919744
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 0.919744
GPM6A glycoprotein M6A 0.919744
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.919744
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.919744
TMEM182 transmembrane protein 182 0.919744
C5ORF56 chromosome 5 open reading frame 56 0.90082
FAS Fas cell surface death receptor 0.899912
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.899912
FOXP1 forkhead box P1 0.899912
LOC100132735 uncharacterized LOC100132735 0.899912
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.899912
MPRIP myosin phosphatase Rho interacting protein 0.899912
CNN1 calponin 1, basic, smooth muscle 0.899912
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.899912
GRM3 glutamate receptor, metabotropic 3 0.899912
MTSS1 metastasis suppressor 1 0.899912
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.899912
EFCAB6 EF-hand calcium binding domain 6 0.899912
CEP170B centrosomal protein 170B 0.882984
DNAH10 dynein, axonemal, heavy chain 10 0.882984
SYT9 synaptotagmin IX 0.882984
BEND7 BEN domain containing 7 0.882984
DNAL4 dynein, axonemal, light chain 4 0.882984
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 0.882984
GPR158 G protein-coupled receptor 158 0.882984
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.882984
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 0.882984
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 0.882984
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.882984
SIK2 salt-inducible kinase 2 0.869746
ATF6 activating transcription factor 6 0.868241
TTLL2 tubulin tyrosine ligase-like family member 2 0.868241
PAPD4 PAP associated domain containing 4 0.868241
IGFBP7 insulin-like growth factor binding protein 7 0.868241
TEK TEK tyrosine kinase, endothelial 0.868241
HRH1 histamine receptor H1 0.868241
TMEM255B transmembrane protein 255B 0.868241
LOC643962 uncharacterized LOC643962 0.868241
CNTNAP2 contactin associated protein-like 2 0.868241
DNASE2B deoxyribonuclease II beta 0.868241
DNER delta/notch-like EGF repeat containing 0.868241
TBC1D14 TBC1 domain family, member 14 0.868241
PROX2 prospero homeobox 2 0.868241
SYNGR1 synaptogyrin 1 0.868241
LOC100132731 uncharacterized LOC100132731 0.868241
HUNK hormonally up-regulated Neu-associated kinase 0.868241
PRKD1 protein kinase D1 0.868241
CADPS Ca++-dependent secretion activator 0.868241
MON2 MON2 homolog (S. cerevisiae) 0.868241
PTGFR prostaglandin F receptor (FP) 0.855449
PTPRR protein tyrosine phosphatase, receptor type, R 0.855449
PRICKLE2 prickle homolog 2 (Drosophila) 0.855449
LRP1B low density lipoprotein receptor-related protein 1B 0.855449
PLCH1 phospholipase C, eta 1 0.855449
RAB3C RAB3C, member RAS oncogene family 0.855449
MEF2BNB-MEF2B MEF2BNB-MEF2B readthrough 0.855449
MEGF10 multiple EGF-like-domains 10 0.855449
DOCK2 dedicator of cytokinesis 2 0.855449
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.855449
UMODL1 uromodulin-like 1 0.855449
EMC9 ER membrane protein complex subunit 9 0.855449
PNOC prepronociceptin 0.855449
UBAP2 ubiquitin associated protein 2 0.85521
HLA-H major histocompatibility complex, class I, H (pseudogene) 0.851472
ZNRD1-AS1 ZNRD1 antisense RNA 1 0.850788
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.829801
C2ORF83 chromosome 2 open reading frame 83 0.828922
HLA-J major histocompatibility complex, class I, J (pseudogene) 0.827192
HDAC4 histone deacetylase 4 0.818279
CASR calcium-sensing receptor 0.815267
NRCAM neuronal cell adhesion molecule 0.810722
HSF2BP heat shock transcription factor 2 binding protein 0.797753
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.797124
MSI2 musashi RNA-binding protein 2 0.795267
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.792855
DOT1L DOT1-like histone H3K79 methyltransferase 0.784165
MICA MHC class I polypeptide-related sequence A 0.784165
TBC1D31 TBC1 domain family, member 31 0.781192
PCDH15 protocadherin-related 15 0.776638
CD86 CD86 molecule 0.767696
CARD14 caspase recruitment domain family, member 14 0.749505
MAK male germ cell-associated kinase 0.748581
TRIM26 tripartite motif containing 26 0.743226
C17ORF99 chromosome 17 open reading frame 99 0.743226
LAMC3 laminin, gamma 3 0.731489
NRP1 neuropilin 1 0.730213
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.722505
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.72096
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.720577
FMN2 formin 2 0.719817
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 0.719439
CSTA cystatin A (stefin A) 0.719063
RFC3 replication factor C (activator 1) 3, 38kDa 0.714661
LOC440600 uncharacterized LOC440600 0.700393
MTCL1 microtubule crosslinking factor 1 0.700393
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.697013
SHROOM3 shroom family member 3 0.694714
CNTN4 contactin 4 0.688128
MYH13 myosin, heavy chain 13, skeletal muscle 0.687222
MAP2 microtubule-associated protein 2 0.679359
EDAR ectodysplasin A receptor 0.677826
FAM162A family with sequence similarity 162, member A 0.673945
FAXC failed axon connections homolog (Drosophila) 0.67336
ECT2L epithelial cell transforming 2 like 0.672779
IRF8 interferon regulatory factor 8 0.669923
HCG9 HLA complex group 9 (non-protein coding) 0.668247
TMPRSS7 transmembrane protease, serine 7 0.666327
DRD2 dopamine receptor D2 0.661809
CDK6 cyclin-dependent kinase 6 0.661549
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.658991
CD80 CD80 molecule 0.658236
C15ORF40 chromosome 15 open reading frame 40 0.652869
GSK3B glycogen synthase kinase 3 beta 0.650522
LVRN laeverin 0.649829
KCNIP1 Kv channel interacting protein 1 0.648884
OR10J1 olfactory receptor, family 10, subfamily J, member 1 0.646119
RELN reelin 0.644396
ASTL astacin-like metallo-endopeptidase (M12 family) 0.643425
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.637546
GDE1 glycerophosphodiester phosphodiesterase 1 0.633071
RORA RAR-related orphan receptor A 0.632634
ETV5 ets variant 5 0.627736
PARP9 poly (ADP-ribose) polymerase family, member 9 0.627321
PTPDC1 protein tyrosine phosphatase domain containing 1 0.624663
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.62227
KIF26B kinesin family member 26B 0.621094
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.618783
ADGRB1 adhesion G protein-coupled receptor B1 0.617083
PTPRG protein tyrosine phosphatase, receptor type, G 0.616311
AHI1 Abelson helper integration site 1 0.614969
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.613457
ARHGAP31 Rho GTPase activating protein 31 0.603282
TRIM31 tripartite motif containing 31 0.600931
SRL sarcalumenin 0.599941
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.599122
SETBP1 SET binding protein 1 0.595129
CADM3 cell adhesion molecule 3 0.592197
CELF1 CUGBP, Elav-like family member 1 0.591289
FGGY FGGY carbohydrate kinase domain containing 0.590688
GRM5 glutamate receptor, metabotropic 5 0.589497
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.587592
MAP6D1 MAP6 domain containing 1 0.585507
OSBPL10 oxysterol binding protein-like 10 0.585136
ZNF622 zinc finger protein 622 0.582338
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.579976
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 0.578246
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.573685
MARC1 mitochondrial amidoxime reducing component 1 0.569663
TK1 thymidine kinase 1, soluble 0.56762
RYR3 ryanodine receptor 3 0.563675
LRP6 low density lipoprotein receptor-related protein 6 0.558007
PDE4D phosphodiesterase 4D, cAMP-specific 0.558007
MYO18B myosin XVIIIB 0.557335
FOXN3 forkhead box N3 0.55667
DACH2 dachshund family transcription factor 2 0.553442
RAB11FIP4 RAB11 family interacting protein 4 (class II) 0.552815
ZNF185 zinc finger protein 185 (LIM domain) 0.550365
PHACTR2 phosphatase and actin regulator 2 0.548586
CAMKMT calmodulin-lysine N-methyltransferase 0.547426
DNMBP dynamin binding protein 0.542984
ARHGAP30 Rho GTPase activating protein 30 0.541144
GLIS3 GLIS family zinc finger 3 0.53868
RHBG Rh family, B glycoprotein (gene/pseudogene) 0.534811
CD46 CD46 molecule, complement regulatory protein 0.534439
FAM167A family with sequence similarity 167, member A 0.531908
CCDC50 coiled-coil domain containing 50 0.530172
MYEOV2 myeloma overexpressed 2 0.529494
GUCD1 guanylyl cyclase domain containing 1 0.528492
C1ORF87 chromosome 1 open reading frame 87 0.525969
CNTN6 contactin 6 0.525969
NCAM1 neural cell adhesion molecule 1 0.52446
ARHGAP21 Rho GTPase activating protein 21 0.523576
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.523285
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 0.523285
TMEM30C transmembrane protein 30C 0.522995
GREM2 gremlin 2, DAN family BMP antagonist 0.522421
CHD6 chromodomain helicase DNA binding protein 6 0.520187
LOC646736 uncharacterized LOC646736 0.515005
GXYLT1 glucoside xylosyltransferase 1 0.512008
ELL elongation factor RNA polymerase II 0.511041
NUB1 negative regulator of ubiquitin-like proteins 1 0.510564
TACR1 tachykinin receptor 1 0.509857
RSU1 Ras suppressor protein 1 0.509159
SULF2 sulfatase 2 0.508699
TPRG1 tumor protein p63 regulated 1 0.508471
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.508244
TECR trans-2,3-enoyl-CoA reductase 0.507122
DYSF dysferlin 0.50668
SORBS2 sorbin and SH3 domain containing 2 0.506461
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.504738
APCDD1L adenomatosis polyposis coli down-regulated 1-like 0.49961
FBLN1 fibulin 1 0.499404
CHODL chondrolectin 0.496997
TULP4 tubby like protein 4 0.493579
MRPL53 mitochondrial ribosomal protein L53 0.490369
CLHC1 clathrin heavy chain linker domain containing 1 0.490024
MOGS mannosyl-oligosaccharide glucosidase 0.488332
B3GALTL beta 1,3-galactosyltransferase-like 0.488001
PCLO piccolo presynaptic cytomatrix protein 0.485988
RRP1B ribosomal RNA processing 1B 0.485639
NALCN sodium leak channel, non selective 0.484947
MYO5C myosin VC 0.483254
KCTD14 potassium channel tetramerization domain containing 14 0.4797
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.47725
CDH23 cadherin-related 23 0.476064
RAD51B RAD51 paralog B 0.474617
IYD iodotyrosine deiodinase 0.468945
MUC22 mucin 22 0.453933
KIAA1107 KIAA1107 0.444358
CHN2 chimerin 2 0.352873
LINC00547 long intergenic non-protein coding RNA 547 0.351193