abnormal immature b cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity (Mammalian Phenotype Ontology, MP_0005022)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005022
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Genes

101 gene mutations causing the abnormal immature b cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKAP13 A kinase (PRKA) anchor protein 13
AR androgen receptor
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATM ATM serine/threonine kinase
ATP11C ATPase, class VI, type 11C
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BMF Bcl2 modifying factor
BST1 bone marrow stromal cell antigen 1
BTK Bruton agammaglobulinemia tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CD22 CD22 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD69 CD69 molecule
CD72 CD72 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
COMMD3-BMI1 COMMD3-BMI1 readthrough
CREBBP CREB binding protein
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
CYLD cylindromatosis (turban tumor syndrome)
DCLRE1C DNA cross-link repair 1C
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DLK1 delta-like 1 homolog (Drosophila)
EPS15 epidermal growth factor receptor pathway substrate 15
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
FAS Fas cell surface death receptor
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT3LG fms-related tyrosine kinase 3 ligand
FNIP1 folliculin interacting protein 1
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GON4L gon-4-like (C. elegans)
HAX1 HCLS1 associated protein X-1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RG interleukin 2 receptor, gamma
IL7R interleukin 7 receptor
IRF8 interferon regulatory factor 8
JAK3 Janus kinase 3
KAT6A K(lysine) acetyltransferase 6A
KLHL6 kelch-like family member 6
LTA lymphotoxin alpha
LYN LYN proto-oncogene, Src family tyrosine kinase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSI2 musashi RNA-binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTSS1 metastasis suppressor 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
PAX5 paired box 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POU2AF1 POU class 2 associating factor 1
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAD50 RAD50 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SH2D1A SH2 domain containing 1A
SH3BP2 SH3-domain binding protein 2
SOX4 SRY (sex determining region Y)-box 4
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPNS2 spinster homolog 2 (Drosophila)
SPPL2A signal peptide peptidase like 2A
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYK spleen tyrosine kinase
TCF12 transcription factor 12
TCF3 transcription factor 3
TDP2 tyrosyl-DNA phosphodiesterase 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TRAF2 TNF receptor-associated factor 2
TRAF3IP2 TRAF3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TWSG1 twisted gastrulation BMP signaling modulator 1
VAV1 vav 1 guanine nucleotide exchange factor
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB1 zinc finger and BTB domain containing 1