abnormal igm level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the normal levels of immunoglobulin class M level (Mammalian Phenotype Ontology, MP_0020180)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0020180
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Genes

174 gene mutations causing the abnormal igm level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
APOE apolipoprotein E
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP11C ATPase, class VI, type 11C
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BATF basic leucine zipper transcription factor, ATF-like
BCL10 B-cell CLL/lymphoma 10
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BLM Bloom syndrome, RecQ helicase-like
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
C1QBP complement component 1, q subcomponent binding protein
CARD11 caspase recruitment domain family, member 11
CCDC171 coiled-coil domain containing 171
CCR6 chemokine (C-C motif) receptor 6
CD19 CD19 molecule
CD22 CD22 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD69 CD69 molecule
CD72 CD72 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CD83 CD83 molecule
CIITA class II, major histocompatibility complex, transactivator
COMMD3-BMI1 COMMD3-BMI1 readthrough
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTSS cathepsin S
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNL drebrin-like
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DOCK8 dedicator of cytokinesis 8
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EBF1 early B-cell factor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCMR Fc fragment of IgM receptor
FLT3LG fms-related tyrosine kinase 3 ligand
FNIP1 folliculin interacting protein 1
FOXP3 forkhead box P3
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPB2 GA binding protein transcription factor, beta subunit 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAPT GRB2-binding adaptor protein, transmembrane
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HDAC6 histone deacetylase 6
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC4 homeobox C4
HR hair growth associated
HRH1 histamine receptor H1
ICOSLG inducible T-cell co-stimulator ligand
IFNG interferon, gamma
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL5RA interleukin 5 receptor, alpha
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF4 interferon regulatory factor 4
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK1 Janus kinase 1
JCHAIN joining chain of multimeric IgA and IgM
LAMA2 laminin, alpha 2
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LIG4 ligase IV, DNA, ATP-dependent
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY86 lymphocyte antigen 86
LYN LYN proto-oncogene, Src family tyrosine kinase
MALT1 MALT1 paracaspase
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MARK2 MAP/microtubule affinity-regulating kinase 2
MAVS mitochondrial antiviral signaling protein
MIR150 microRNA 150
MIR155 microRNA 155
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NHEJ1 nonhomologous end-joining factor 1
NIPAL3 NIPA-like domain containing 3
NPY1R neuropeptide Y receptor Y1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PITX3 paired-like homeodomain 3
PKN1 protein kinase N1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCL2 phospholipase C-like 2
POLQ polymerase (DNA directed), theta
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PPARG peroxisome proliferator-activated receptor gamma
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKD2 protein kinase D2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTTG1 pituitary tumor-transforming 1
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS13 regulator of G-protein signaling 13
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RUVBL2 RuvB-like AAA ATPase 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SASH3 SAM and SH3 domain containing 3
SFN stratifin
SH2D1A SH2 domain containing 1A
SH2D3C SH2 domain containing 3C
SH3BP2 SH3-domain binding protein 2
SHARPIN SHANK-associated RH domain interactor
SIAE sialic acid acetylesterase
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIGLEC10 sialic acid binding Ig-like lectin 10
SKAP2 src kinase associated phosphoprotein 2
SPI1 Spi-1 proto-oncogene
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPPL2A signal peptide peptidase like 2A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNIP1 TNFAIP3 interacting protein 1
TRAF5 TNF receptor-associated factor 5
TROVE2 TROVE domain family, member 2
UNG uracil-DNA glycosylase
VAV2 vav 2 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZC3H12A zinc finger CCCH-type containing 12A
ZEB1 zinc finger E-box binding homeobox 1
ZNF318 zinc finger protein 318