abnormal igg2a level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the normal levels of immunoglobulin class G2a level (Mammalian Phenotype Ontology, MP_0020176)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0020176
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Genes

128 gene mutations causing the abnormal igg2a level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
AVPR1A arginine vasopressin receptor 1A
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BTLA B and T lymphocyte associated
CARD11 caspase recruitment domain family, member 11
CCR1 chemokine (C-C motif) receptor 1
CCR7 chemokine (C-C motif) receptor 7
CD180 CD180 molecule
CD19 CD19 molecule
CD22 CD22 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD69 CD69 molecule
CD83 CD83 molecule
CH25H cholesterol 25-hydroxylase
CR2 complement component (3d/Epstein Barr virus) receptor 2
CXCL10 chemokine (C-X-C motif) ligand 10
CYLD cylindromatosis (turban tumor syndrome)
DHRS4 dehydrogenase/reductase (SDR family) member 4
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FLG filaggrin
FNIP1 folliculin interacting protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HAX1 HCLS1 associated protein X-1
HOXC4 homeobox C4
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL13 interleukin 13
IL13RA2 interleukin 13 receptor, alpha 2
IL17A interleukin 17A
IL17F interleukin 17F
IL2 interleukin 2
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF2 interferon regulatory factor 2
ITFG2 integrin alpha FG-GAP repeat containing 2
ITPKB inositol-trisphosphate 3-kinase B
JAK1 Janus kinase 1
LAX1 lymphocyte transmembrane adaptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAVS mitochondrial antiviral signaling protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NIPAL3 NIPA-like domain containing 3
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKN1 protein kinase N1
POU2AF1 POU class 2 associating factor 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PVR poliovirus receptor
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RCAN1 regulator of calcineurin 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RETNLB resistin like beta
RFTN1 raftlin, lipid raft linker 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
SASH3 SAM and SH3 domain containing 3
SH2D1A SH2 domain containing 1A
SIAE sialic acid acetylesterase
SIGLEC10 sialic acid binding Ig-like lectin 10
SKAP2 src kinase associated phosphoprotein 2
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPPL2A signal peptide peptidase like 2A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TICAM1 toll-like receptor adaptor molecule 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNIP1 TNFAIP3 interacting protein 1
TROVE2 TROVE domain family, member 2
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
ZC3H12A zinc finger CCCH-type containing 12A