abnormal igg1 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the normal levels of immunoglobulin class G1 level (Mammalian Phenotype Ontology, MP_0020175)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0020175
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Genes

180 gene mutations causing the abnormal igg1 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCY9 adenylate cyclase 9
AICDA activation-induced cytidine deaminase
AKAP13 A kinase (PRKA) anchor protein 13
AMPD3 adenosine monophosphate deaminase 3
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP11C ATPase, class VI, type 11C
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BTLA B and T lymphocyte associated
C3AR1 complement component 3a receptor 1
CABIN1 calcineurin binding protein 1
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CARD11 caspase recruitment domain family, member 11
CCL13 chemokine (C-C motif) ligand 13
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CD22 CD22 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD37 CD37 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHD7 chromodomain helicase DNA binding protein 7
CLUAP1 clusterin associated protein 1
CR2 complement component (3d/Epstein Barr virus) receptor 2
CYLD cylindromatosis (turban tumor syndrome)
DBNL drebrin-like
DLK1 delta-like 1 homolog (Drosophila)
DLL1 delta-like 1 (Drosophila)
DUSP4 dual specificity phosphatase 4
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCMR Fc fragment of IgM receptor
FCRLA Fc receptor-like A
FCRLB Fc receptor-like B
FLG filaggrin
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FNIP1 folliculin interacting protein 1
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
GABPB2 GA binding protein transcription factor, beta subunit 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAP43 growth associated protein 43
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GPR132 G protein-coupled receptor 132
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC4 homeobox C4
HRH4 histamine receptor H4
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL17A interleukin 17A
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6ST interleukin 6 signal transducer
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
ITPKB inositol-trisphosphate 3-kinase B
JAK1 Janus kinase 1
KDM8 lysine (K)-specific demethylase 8
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LAX1 lymphocyte transmembrane adaptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAVS mitochondrial antiviral signaling protein
MIR150 microRNA 150
MIR155 microRNA 155
MSH2 mutS homolog 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYD88 myeloid differentiation primary response 88
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NHEJ1 nonhomologous end-joining factor 1
NLRP10 NLR family, pyrin domain containing 10
NUP98 nucleoporin 98kDa
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKN1 protein kinase N1
POLQ polymerase (DNA directed), theta
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKCD protein kinase C, delta
PRKD2 protein kinase D2
PRMT8 protein arginine methyltransferase 8
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PVR poliovirus receptor
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETNLB resistin like beta
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS13 regulator of G-protein signaling 13
RIF1 replication timing regulatory factor 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RSAD2 radical S-adenosyl methionine domain containing 2
RUVBL2 RuvB-like AAA ATPase 2
SASH3 SAM and SH3 domain containing 3
SDC1 syndecan 1
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SH2D1A SH2 domain containing 1A
SH2D3C SH2 domain containing 3C
SH3BP2 SH3-domain binding protein 2
SIAE sialic acid acetylesterase
SNX5 sorting nexin 5
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPNS2 spinster homolog 2 (Drosophila)
SPPL2A signal peptide peptidase like 2A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNIP1 TNFAIP3 interacting protein 1
TRAF3IP2 TRAF3 interacting protein 2
TRAF5 TNF receptor-associated factor 5
TYK2 tyrosine kinase 2
UXS1 UDP-glucuronate decarboxylase 1
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZC3H12A zinc finger CCCH-type containing 12A
ZEB1 zinc finger E-box binding homeobox 1