abnormal igg level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the normal levels of immunoglobulin class G level (Mammalian Phenotype Ontology, MP_0020174)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0020174
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Genes

324 gene mutations causing the abnormal igg level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCY9 adenylate cyclase 9
AICDA activation-induced cytidine deaminase
AKAP13 A kinase (PRKA) anchor protein 13
AMPD3 adenosine monophosphate deaminase 3
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
ATP11C ATPase, class VI, type 11C
AVPR1A arginine vasopressin receptor 1A
B2M beta-2-microglobulin
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BATF basic leucine zipper transcription factor, ATF-like
BCL10 B-cell CLL/lymphoma 10
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BST1 bone marrow stromal cell antigen 1
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3AR1 complement component 3a receptor 1
CABIN1 calcineurin binding protein 1
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CARD11 caspase recruitment domain family, member 11
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD180 CD180 molecule
CD19 CD19 molecule
CD1D CD1d molecule
CD22 CD22 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD37 CD37 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD69 CD69 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CD83 CD83 molecule
CD84 CD84 molecule
CD86 CD86 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CH25H cholesterol 25-hydroxylase
CHD7 chromodomain helicase DNA binding protein 7
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLK1 CDC-like kinase 1
CLUAP1 clusterin associated protein 1
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNL drebrin-like
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DHRS4 dehydrogenase/reductase (SDR family) member 4
DLK1 delta-like 1 homolog (Drosophila)
DLL1 delta-like 1 (Drosophila)
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
DUSP4 dual specificity phosphatase 4
EFS embryonal Fyn-associated substrate
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCMR Fc fragment of IgM receptor
FCRLA Fc receptor-like A
FCRLB Fc receptor-like B
FLG filaggrin
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FNIP1 folliculin interacting protein 1
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPB2 GA binding protein transcription factor, beta subunit 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GAP43 growth associated protein 43
GAPT GRB2-binding adaptor protein, transmembrane
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR132 G protein-coupled receptor 132
H2AFX H2A histone family, member X
HAX1 HCLS1 associated protein X-1
HDAC6 histone deacetylase 6
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC4 homeobox C4
HR hair growth associated
HRH1 histamine receptor H1
HRH4 histamine receptor H4
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHD immunoglobulin heavy constant delta
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPKB inositol-trisphosphate 3-kinase B
JAK1 Janus kinase 1
JAK3 Janus kinase 3
JCHAIN joining chain of multimeric IgA and IgM
KDM8 lysine (K)-specific demethylase 8
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMA2 laminin, alpha 2
LAT linker for activation of T cells
LAX1 lymphocyte transmembrane adaptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS3 lectin, galactoside-binding, soluble, 3
LIG4 ligase IV, DNA, ATP-dependent
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY86 lymphocyte antigen 86
LYN LYN proto-oncogene, Src family tyrosine kinase
MALT1 MALT1 paracaspase
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MARK2 MAP/microtubule affinity-regulating kinase 2
MAVS mitochondrial antiviral signaling protein
MIR150 microRNA 150
MIR155 microRNA 155
MSH2 mutS homolog 2
MTA3 metastasis associated 1 family, member 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYD88 myeloid differentiation primary response 88
MYO6 myosin VI
MYSM1 Myb-like, SWIRM and MPN domains 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NHEJ1 nonhomologous end-joining factor 1
NIPAL3 NIPA-like domain containing 3
NLRP10 NLR family, pyrin domain containing 10
NLRP6 NLR family, pyrin domain containing 6
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
NUP98 nucleoporin 98kDa
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PIGR polymeric immunoglobulin receptor
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PITX3 paired-like homeodomain 3
PKN1 protein kinase N1
POLB polymerase (DNA directed), beta
POLQ polymerase (DNA directed), theta
POMT1 protein-O-mannosyltransferase 1
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKD2 protein kinase D2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT8 protein arginine methyltransferase 8
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTTG1 pituitary tumor-transforming 1
PVR poliovirus receptor
PYCARD PYD and CARD domain containing
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
RCAN1 regulator of calcineurin 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETNLB resistin like beta
RFTN1 raftlin, lipid raft linker 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS13 regulator of G-protein signaling 13
RIF1 replication timing regulatory factor 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RSAD2 radical S-adenosyl methionine domain containing 2
RUVBL2 RuvB-like AAA ATPase 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SASH3 SAM and SH3 domain containing 3
SCARF1 scavenger receptor class F, member 1
SDC1 syndecan 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SFN stratifin
SH2B2 SH2B adaptor protein 2
SH2D1A SH2 domain containing 1A
SH2D3C SH2 domain containing 3C
SH3BP2 SH3-domain binding protein 2
SHARPIN SHANK-associated RH domain interactor
SIAE sialic acid acetylesterase
SIGLEC10 sialic acid binding Ig-like lectin 10
SKAP2 src kinase associated phosphoprotein 2
SNX5 sorting nexin 5
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPNS2 spinster homolog 2 (Drosophila)
SPPL2A signal peptide peptidase like 2A
SPTA1 spectrin, alpha, erythrocytic 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
SYTL1 synaptotagmin-like 1
TANK TRAF family member-associated NFKB activator
TBC1D10C TBC1 domain family, member 10C
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TICAM1 toll-like receptor adaptor molecule 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNIP1 TNFAIP3 interacting protein 1
TRADD TNFRSF1A-associated via death domain
TRAF3IP2 TRAF3 interacting protein 2
TRAF5 TNF receptor-associated factor 5
TREX1 three prime repair exonuclease 1
TRIP10 thyroid hormone receptor interactor 10
TROVE2 TROVE domain family, member 2
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
UNG uracil-DNA glycosylase
UXS1 UDP-glucuronate decarboxylase 1
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZC3H12A zinc finger CCCH-type containing 12A
ZEB1 zinc finger E-box binding homeobox 1