abnormal ige level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the normal levels of immunoglobulin class E level (Mammalian Phenotype Ontology, MP_0020173)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0020173
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Genes

107 gene mutations causing the abnormal ige level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BATF basic leucine zipper transcription factor, ATF-like
BHLHE40 basic helix-loop-helix family, member e40
BTK Bruton agammaglobulinemia tyrosine kinase
C3AR1 complement component 3a receptor 1
CABIN1 calcineurin binding protein 1
CARD11 caspase recruitment domain family, member 11
CCR4 chemokine (C-C motif) receptor 4
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSE cathepsin E
CXCR2 chemokine (C-X-C motif) receptor 2
DSG3 desmoglein 3
DSG4 desmoglein 4
ECM1 extracellular matrix protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FLG filaggrin
FNIP1 folliculin interacting protein 1
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
HMGN5 high mobility group nucleosome binding domain 5
HOXC4 homeobox C4
HRH4 histamine receptor H4
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFITM1 interferon induced transmembrane protein 1
IFNG interferon, gamma
IGHD immunoglobulin heavy constant delta
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL17A interleukin 17A
IL17RB interleukin 17 receptor B
IL1RL1 interleukin 1 receptor-like 1
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL25 interleukin 25
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL31RA interleukin 31 receptor A
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ITFG2 integrin alpha FG-GAP repeat containing 2
ITK IL2-inducible T-cell kinase
LAT linker for activation of T cells
LAX1 lymphocyte transmembrane adaptor 1
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LPAR2 lysophosphatidic acid receptor 2
LTB4R leukotriene B4 receptor
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MMP9 matrix metallopeptidase 9
MYD88 myeloid differentiation primary response 88
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NIPAL3 NIPA-like domain containing 3
PIGR polymeric immunoglobulin receptor
PLA2G10 phospholipase A2, group X
POU2AF1 POU class 2 associating factor 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGDR2 prostaglandin D2 receptor 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RORA RAR-related orphan receptor A
RUNX3 runt-related transcription factor 3
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SH2D1A SH2 domain containing 1A
SHARPIN SHANK-associated RH domain interactor
SIAE sialic acid acetylesterase
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SWAP70 SWAP switching B-cell complex 70kDa subunit
TMEM79 transmembrane protein 79
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIP1 TNFAIP3 interacting protein 1
TRAF3IP2 TRAF3 interacting protein 2
TRIP10 thyroid hormone receptor interactor 10
VIPR2 vasoactive intestinal peptide receptor 2
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa