abnormal hyperactivated sperm motility Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the type of sperm motility that is observed in most sperm recovered from the site of fertilization and is thought to help sperm detach from the oviductal epithelium, reach the site of fertilization, and penetrate the cumulus and zona pellucida of the oocyte; normally, once sperm from most species become hyperactivated, the flagellar beat becomes asymmetrical and higher amplitude, resulting in circular or figure-eight trajectories (Mammalian Phenotype Ontology, MP_0009281)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009281
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Genes

4 gene mutations causing the abnormal hyperactivated sperm motility phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AKAP4 A kinase (PRKA) anchor protein 4
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
CATSPERD catsper channel auxiliary subunit delta
PCSK4 proprotein convertase subtilisin/kexin type 4