abnormal harderian gland morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the retroocular sebaceous gland found within the orbit of mammals that possess a nictitating membrane (third eyelid); the chief products of the gland vary between different groups of vertebrates, and epithelial cells possess granules or vacuoles whose contents may be mucous, serous or lipid; in rodents, the Harderian gland is especially large and secretes lipids (by a merocrine mechanism), melatonin and porphyrins; ascribed functions include a role in lubrication and protection for the eyeball and nictitating membrane (by lipids), photoprotection (by porphyrin), photoreception (by regulation of the incidence of light on the retina), and thermoregulation (in some rodents) of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane (Mammalian Phenotype Ontology, MP_0005248)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005248
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12 gene mutations causing the abnormal harderian gland morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
FGF10 fibroblast growth factor 10
FIGN fidgetin
GLI3 GLI family zinc finger 3
MITF microphthalmia-associated transcription factor
OTX1 orthodenticle homeobox 1
PRLR prolactin receptor
RAB27A RAB27A, member RAS oncogene family
RARG retinoic acid receptor, gamma
RXRA retinoid X receptor, alpha
VSX2 visual system homeobox 2