abnormal granulocyte differentiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils (Mammalian Phenotype Ontology, MP_0008111)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008111
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Genes

30 gene mutations causing the abnormal granulocyte differentiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CSF3R colony stimulating factor 3 receptor (granulocyte)
CXCR2 chemokine (C-X-C motif) receptor 2
GAB2 GRB2-associated binding protein 2
GFI1 growth factor independent 1 transcription repressor
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10RB interleukin 10 receptor, beta
IL17RA interleukin 17 receptor A
IL3 interleukin 3
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KMT2E lysine (K)-specific methyltransferase 2E
LBR lamin B receptor
MECOM MDS1 and EVI1 complex locus
MIR223 microRNA 223
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PLA2G3 phospholipase A2, group III
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCD1 phospholipase C, delta 1
PLSCR1 phospholipid scramblase 1
PTPRC protein tyrosine phosphatase, receptor type, C
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SENP1 SUMO1/sentrin specific peptidase 1
SH2B3 SH2B adaptor protein 3
SIGLEC8 sialic acid binding Ig-like lectin 8
SIN3B SIN3 transcription regulator family member B
SPI1 Spi-1 proto-oncogene
STAT5A signal transducer and activator of transcription 5A