abnormal glucose tolerance Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral or intravenous administration of glucose. (Human Phenotype Ontology, HP_0001952)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005291
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Genes

328 gene mutations causing the abnormal glucose tolerance phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACADVL acyl-CoA dehydrogenase, very long chain
ACOT11 acyl-CoA thioesterase 11
ACOT13 acyl-CoA thioesterase 13
ACTB actin, beta
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADGRF5 adhesion G protein-coupled receptor F5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA1B adrenoceptor alpha 1B
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHSG alpha-2-HS-glycoprotein
AKAP5 A kinase (PRKA) anchor protein 5
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALX3 ALX homeobox 3
ANGPTL2 angiopoietin-like 2
APOE apolipoprotein E
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ASIP agouti signaling protein
ATF4 activating transcription factor 4
ATG3 autophagy related 3
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAD BCL2-associated agonist of cell death
BBS5 Bardet-Biedl syndrome 5
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BGLAP bone gamma-carboxyglutamate (gla) protein
BRD2 bromodomain containing 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CADPS2 Ca++-dependent secretion activator 2
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CARTPT CART prepropeptide
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC80 coiled-coil domain containing 80
CCL13 chemokine (C-C motif) ligand 13
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD38 CD38 molecule
CDH23 cadherin-related 23
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPJ centromere protein J
CEP19 centrosomal protein 19kDa
CERS6 ceramide synthase 6
CES1 carboxylesterase 1
CHGB chromogranin B
CHRM3 cholinergic receptor, muscarinic 3
CIDEC cell death-inducing DFFA-like effector c
CISD2 CDGSH iron sulfur domain 2
CLOCK clock circadian regulator
CNOT3 CCR4-NOT transcription complex, subunit 3
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A3 collagen, type V, alpha 3
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung)
CPE carboxypeptidase E
CRBN cereblon
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRTC1 CREB regulated transcription coactivator 1
CSMD1 CUB and Sushi multiple domains 1
CSPG4 chondroitin sulfate proteoglycan 4
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R4 cytochrome b5 reductase 4
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DBN1 drebrin 1
DDIT3 DNA-damage-inducible transcript 3
DGAT1 diacylglycerol O-acyltransferase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPP4 dipeptidyl-peptidase 4
E2F1 E2F transcription factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EMC10 ER membrane protein complex subunit 10
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPM2AIP1 EPM2A (laforin) interacting protein 1
ERO1LB ERO1-like beta (S. cerevisiae)
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3B family with sequence similarity 3, member B
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FEM1B fem-1 homolog b (C. elegans)
FFAR1 free fatty acid receptor 1
FFAR2 free fatty acid receptor 2
FFAR3 free fatty acid receptor 3
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FGL1 fibrinogen-like 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXA1 forkhead box A1
FOXO3 forkhead box O3
FSTL3 follistatin-like 3 (secreted glycoprotein)
FTO fat mass and obesity associated
G0S2 G0/G1 switch 2
GAST gastrin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCG glucagon
GCGR glucagon receptor
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GDF3 growth differentiation factor 3
GEM GTP binding protein overexpressed in skeletal muscle
GHRL ghrelin/obestatin prepropeptide
GIPR gastric inhibitory polypeptide receptor
GLIS3 GLIS family zinc finger 3
GLP1R glucagon-like peptide 1 receptor
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAS GNAS complex locus
GPBAR1 G protein-coupled bile acid receptor 1
GPER1 G protein-coupled estrogen receptor 1
GPR21 G protein-coupled receptor 21
GPR26 G protein-coupled receptor 26
GPRC6A G protein-coupled receptor, class C, group 6, member A
GRB14 growth factor receptor-bound protein 14
GSK3A glycogen synthase kinase 3 alpha
GSTA4 glutathione S-transferase alpha 4
GUCY2C guanylate cyclase 2C
GYS2 glycogen synthase 2 (liver)
HDC histidine decarboxylase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIPK3 homeodomain interacting protein kinase 3
HMGA1 high mobility group AT-hook 1
HMGN3 high mobility group nucleosomal binding domain 3
HMGN5 high mobility group nucleosome binding domain 5
HNF4A hepatocyte nuclear factor 4, alpha
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IAPP islet amyloid polypeptide
IDE insulin-degrading enzyme
IFT88 intraflagellar transport 88
IGFBP4 insulin-like growth factor binding protein 4
IL10RB interleukin 10 receptor, beta
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
ILDR2 immunoglobulin-like domain containing receptor 2
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSL5 insulin-like 5
INSR insulin receptor
IP6K1 inositol hexakisphosphate kinase 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KL klotho
KLF15 Kruppel-like factor 15
KMT2B lysine (K)-specific methyltransferase 2B
KPTN kaptin (actin binding protein)
LCMT1 leucine carboxyl methyltransferase 1
LDHA lactate dehydrogenase A
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGALS12 lectin, galactoside-binding, soluble, 12
LPIN1 lipin 1
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LRRN3 leucine rich repeat neuronal 3
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAPK13 mitogen-activated protein kinase 13
MAPK8 mitogen-activated protein kinase 8
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MBD5 methyl-CpG binding domain protein 5
MBOAT4 membrane bound O-acyltransferase domain containing 4
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGLL monoglyceride lipase
MIR184 microRNA 184
MOGAT2 monoacylglycerol O-acyltransferase 2
MRAP2 melanocortin 2 receptor accessory protein 2
MRPS5 mitochondrial ribosomal protein S5
MSTN myostatin
MTMR3 myotubularin related protein 3
MYO7A myosin VIIA
NAMPT nicotinamide phosphoribosyltransferase
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NEUROG3 neurogenin 3
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NLN neurolysin (metallopeptidase M3 family)
NNT nicotinamide nucleotide transhydrogenase
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY1R neuropeptide Y receptor Y1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
OMA1 OMA1 zinc metallopeptidase
ONECUT1 one cut homeobox 1
OPRM1 opioid receptor, mu 1
OSMR oncostatin M receptor
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PAM peptidylglycine alpha-amidating monooxygenase
PASK PAS domain containing serine/threonine kinase
PAX6 paired box 6
PBX1 pre-B-cell leukemia homeobox 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDPK1 3-phosphoinositide dependent protein kinase 1
PDX1 pancreatic and duodenal homeobox 1
PFKM phosphofructokinase, muscle
PGR progesterone receptor
PHOX2A paired-like homeobox 2a
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN1 perilipin 1
PLSCR3 phospholipid scramblase 3
PNPLA2 patatin-like phospholipase domain containing 2
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PRLR prolactin receptor
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRN protein tyrosine phosphatase, receptor type, N
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTRF polymerase I and transcript release factor
PYY peptide YY
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBM4 RNA binding motif protein 4
RBM4B RNA binding motif protein 4B
RCAN2 regulator of calcineurin 2
REG3A regenerating islet-derived 3 alpha
RETN resistin
RGPD1 RANBP2-like and GRIP domain containing 1
RGS10 regulator of G-protein signaling 10
RGS7 regulator of G-protein signaling 7
RIMS2 regulating synaptic membrane exocytosis 2
RMI1 RecQ mediated genome instability 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPS6 ribosomal protein S6
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC3 syndecan 3
SEC16B SEC16 homolog B (S. cerevisiae)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERTAD1 SERTA domain containing 1
SERTAD2 SERTA domain containing 2
SESN2 sestrin 2
SGMS1 sphingomyelin synthase 1
SGMS2 sphingomyelin synthase 2
SH2B1 SH2B adaptor protein 1
SIDT2 SID1 transmembrane family, member 2
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLX4 SLX4 structure-specific endonuclease subunit
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS7 suppressor of cytokine signaling 7
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRA1 steroid receptor RNA activator 1
SSFA2 sperm specific antigen 2
SSTR5 somatostatin receptor 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP4 STEAP family member 4
STRA6 stimulated by retinoic acid 6
STX4 syntaxin 4
STXBP3 syntaxin binding protein 3
TBC1D4 TBC1 domain family, member 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERF2IP telomeric repeat binding factor 2, interacting protein
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
THRA thyroid hormone receptor, alpha
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TRIB1 tribbles pseudokinase 1
TXNIP thioredoxin interacting protein
TYK2 tyrosine kinase 2
UBE3B ubiquitin protein ligase E3B
UCN3 urocortin 3
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UNC13A unc-13 homolog A (C. elegans)
USH1C Usher syndrome 1C (autosomal recessive, severe)
USP22 ubiquitin specific peptidase 22
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIPR1 vasoactive intestinal peptide receptor 1
WFS1 Wolfram syndrome 1 (wolframin)
ZBTB20 zinc finger and BTB domain containing 20
ZEB1 zinc finger E-box binding homeobox 1