abnormal glomerular mesangium morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells (Mammalian Phenotype Ontology, MP_0011339)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011339
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Genes

60 gene mutations causing the abnormal glomerular mesangium morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANK1 ankyrin 1, erythrocytic
APOE apolipoprotein E
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASIP agouti signaling protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CD151 CD151 molecule (Raph blood group)
CD2AP CD2-associated protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFH complement factor H
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FOXC2 forkhead box C2
FRAS1 Fraser extracellular matrix complex subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDNF glial cell derived neurotrophic factor
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPR4 G protein-coupled receptor 4
HPRT1 hypoxanthine phosphoribosyltransferase 1
INS insulin
ITGA1 integrin, alpha 1
JAK1 Janus kinase 1
KIRREL kin of IRRE like (Drosophila)
LAMA5 laminin, alpha 5
LCAT lecithin-cholesterol acyltransferase
LEP leptin
LEPR leptin receptor
LYN LYN proto-oncogene, Src family tyrosine kinase
MARK2 MAP/microtubule affinity-regulating kinase 2
MIR192 microRNA 192
MPV17 MpV17 mitochondrial inner membrane protein
MTA2 metastasis associated 1 family, member 2
MYO1E myosin IE
NFE2L2 nuclear factor, erythroid 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PKN1 protein kinase N1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SCTR secretin receptor
SMAD3 SMAD family member 3
SYK spleen tyrosine kinase
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRAF3IP2 TRAF3 interacting protein 2
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
WT1 Wilms tumor 1