abnormal glial cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons (Mammalian Phenotype Ontology, MP_0003690)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003690
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Genes

63 gene mutations causing the abnormal glial cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ANXA7 annexin A7
APOE apolipoprotein E
AQP4 aquaporin 4
ATM ATM serine/threonine kinase
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCL13 chemokine (C-C motif) ligand 13
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
CLCN2 chloride channel, voltage-sensitive 2
CLCN3 chloride channel, voltage-sensitive 3
CNTF ciliary neurotrophic factor
CP ceruloplasmin (ferroxidase)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DOCK3 dedicator of cytokinesis 3
DRD2 dopamine receptor D2
EGR1 early growth response 1
EGR2 early growth response 2
FZD4 frizzled class receptor 4
GALC galactosylceramidase
GFAP glial fibrillary acidic protein
GJC2 gap junction protein, gamma 2, 47kDa
GRM3 glutamate receptor, metabotropic 3
GRN granulin
IDUA iduronidase, alpha-L-
IFNB1 interferon, beta 1, fibroblast
IL6 interleukin 6
ITGA7 integrin, alpha 7
KIF14 kinesin family member 14
LEP leptin
LGI4 leucine-rich repeat LGI family, member 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2C1 mannosidase, alpha, class 2C, member 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NF1 neurofibromin 1
NFASC neurofascin
NPC1 Niemann-Pick disease, type C1
PARP1 poly (ADP-ribose) polymerase 1
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAT plasminogen activator, tissue
PLG plasminogen
PLP1 proteolipid protein 1
PMP22 peripheral myelin protein 22
PPT1 palmitoyl-protein thioesterase 1
PSAP prosaposin
PTEN phosphatase and tensin homolog
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
S1PR5 sphingosine-1-phosphate receptor 5
SARM1 sterile alpha and TIR motif containing 1
STIP1 stress-induced phosphoprotein 1
TENM4 teneurin transmembrane protein 4
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)