abnormal estrous cycle Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description failure of progression or aberrant timing of the regular female reproductive cycle of non-primate placental mammals that is under hormonal control and includes a period of heat (mating receptivity), followed by ovulation and complex changes in the reproductive tract, followed by reabsorbtion of the endometrium if pregnancy does not occur (Mammalian Phenotype Ontology, MP_0001927)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001927
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Genes

79 gene mutations causing the abnormal estrous cycle phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
AFP alpha-fetoprotein
AKR1C3 aldo-keto reductase family 1, member C3
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATM ATM serine/threonine kinase
BMPR1B bone morphogenetic protein receptor, type IB
C3 complement component 3
CBS cystathionine-beta-synthase
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLOCK clock circadian regulator
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DRD2 dopamine receptor D2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FANCL Fanconi anemia, complementation group L
FOXA2 forkhead box A2
FOXN1 forkhead box N1
FOXO3 forkhead box O3
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GHR growth hormone receptor
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GPR149 G protein-coupled receptor 149
GPR3 G protein-coupled receptor 3
HMGA2 high mobility group AT-hook 2
IL2RG interleukin 2 receptor, gamma
IL5 interleukin 5
INSL3 insulin-like 3 (Leydig cell)
INSL5 insulin-like 5
IRS2 insulin receptor substrate 2
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
LATS1 large tumor suppressor kinase 1
LEP leptin
LEPR leptin receptor
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LHX9 LIM homeobox 9
MAGEL2 melanoma antigen family L2
MITF microphthalmia-associated transcription factor
NCOA3 nuclear receptor coactivator 3
NHLH2 nescient helix loop helix 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NPR2 natriuretic peptide receptor 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTF3 neurotrophin 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PER1 period circadian clock 1
PER2 period circadian clock 2
POSTN periostin, osteoblast specific factor
PRL prolactin
PTPRS protein tyrosine phosphatase, receptor type, S
RORA RAR-related orphan receptor A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SIRT1 sirtuin 1
SRY sex determining region Y
THRA thyroid hormone receptor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNF tumor necrosis factor
TSHR thyroid stimulating hormone receptor
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VGF VGF nerve growth factor inducible