abnormal eosinophil morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions (Mammalian Phenotype Ontology, MP_0005061)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005061
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Genes

86 gene mutations causing the abnormal eosinophil morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACVR2A activin A receptor, type IIA
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP7B ATPase, Cu++ transporting, beta polypeptide
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
C3AR1 complement component 3a receptor 1
CCL11 chemokine (C-C motif) ligand 11
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CD34 CD34 molecule
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CISH cytokine inducible SH2-containing protein
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSE cathepsin E
EP300 E1A binding protein p300
EPX eosinophil peroxidase
FAS Fas cell surface death receptor
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FOXN1 forkhead box N1
FOXP3 forkhead box P3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD9 frizzled class receptor 9
GADD45A growth arrest and DNA-damage-inducible, alpha
GALC galactosylceramidase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPC2 glypican 2
HCK HCK proto-oncogene, Src family tyrosine kinase
ICAM1 intercellular adhesion molecule 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
IL1RL1 interleukin 1 receptor-like 1
IL21R interleukin 21 receptor
IL25 interleukin 25
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB7 integrin, beta 7
KISS1R KISS1 receptor
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LBR lamin B receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LTB4R leukotriene B4 receptor
LYST lysosomal trafficking regulator
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MINA MYC induced nuclear antigen
MMP9 matrix metallopeptidase 9
MYB v-myb avian myeloblastosis viral oncogene homolog
NOS2 nitric oxide synthase 2, inducible
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G10 phospholipase A2, group X
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGDR2 prostaglandin D2 receptor 2
RAG1 recombination activating gene 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SHARPIN SHANK-associated RH domain interactor
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SOCS1 suppressor of cytokine signaling 1
SPRED1 sprouty-related, EVH1 domain containing 1
TBK1 TANK-binding kinase 1
THBS1 thrombospondin 1
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TRIB1 tribbles pseudokinase 1