abnormal emotion/affect behavior Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of emotional behaviour. (Human Phenotype Ontology, HP_0100851)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002572
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Genes

422 gene mutations causing the abnormal emotion/affect behavior phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADGRB2 adhesion G protein-coupled receptor B2
ADGRL3 adhesion G protein-coupled receptor L3
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADRA1B adrenoceptor alpha 1B
ADRA2C adrenoceptor alpha 2C
AFM afamin
AGTR2 angiotensin II receptor, type 2
AKAP5 A kinase (PRKA) anchor protein 5
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANKRD11 ankyrin repeat domain 11
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARC activity-regulated cytoskeleton-associated protein
ARF4 ADP-ribosylation factor 4
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARSG arylsulfatase G
ARX aristaless related homeobox
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPA aspartoacylase
ATAT1 alpha tubulin acetyltransferase 1
ATF7 activating transcription factor 7
ATP13A2 ATPase type 13A2
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
ATXN1 ataxin 1
ATXN3 ataxin 3
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BACE1 beta-site APP-cleaving enzyme 1
BBS1 Bardet-Biedl syndrome 1
BBS2 Bardet-Biedl syndrome 2
BBS4 Bardet-Biedl syndrome 4
BDNF brain-derived neurotrophic factor
C12ORF10 chromosome 12 open reading frame 10
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CADPS2 Ca++-dependent secretion activator 2
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK4 calcium/calmodulin-dependent protein kinase IV
CANX calnexin
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBX7 chromobox homolog 7
CCKBR cholecystokinin B receptor
CD47 CD47 molecule
CDH23 cadherin-related 23
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKL5 cyclin-dependent kinase-like 5
CELF6 CUGBP, Elav-like family member 6
CER1 cerberus 1, DAN family BMP antagonist
CERS1 ceramide synthase 1
CERS6 ceramide synthase 6
CHD6 chromodomain helicase DNA binding protein 6
CHL1 cell adhesion molecule L1-like
CHRD chordin
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CKB creatine kinase, brain
CKMT1A creatine kinase, mitochondrial 1A
CLCN3 chloride channel, voltage-sensitive 3
CLCN6 chloride channel, voltage-sensitive 6
CLOCK clock circadian regulator
CLU clusterin
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPLX2 complexin 2
CREM cAMP responsive element modulator
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSK c-src tyrosine kinase
CSMD1 CUB and Sushi multiple domains 1
CTNS cystinosin, lysosomal cystine transporter
CYB561 cytochrome b561
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DCDC2 doublecortin domain containing 2
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DGCR8 DGCR8 microprocessor complex subunit
DHRS4 dehydrogenase/reductase (SDR family) member 4
DISC1 disrupted in schizophrenia 1
DLG4 discs, large homolog 4 (Drosophila)
DLGAP3 discs, large (Drosophila) homolog-associated protein 3
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DST dystonin
DUSP1 dual specificity phosphatase 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EFNA3 ephrin-A3
EGR1 early growth response 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1
ELMOD1 ELMO/CED-12 domain containing 1
EMC10 ER membrane protein complex subunit 10
EN2 engrailed homeobox 2
EPM2AIP1 EPM2A (laforin) interacting protein 1
ERC2 ELKS/RAB6-interacting/CAST family member 2
ERCC2 excision repair cross-complementation group 2
ESPN espin
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EYA3 EYA transcriptional coactivator and phosphatase 3
FABP7 fatty acid binding protein 7, brain
FAM3D family with sequence similarity 3, member D
FEV FEV (ETS oncogene family)
FGFBP3 fibroblast growth factor binding protein 3
FKBP5 FK506 binding protein 5
FMR1 fragile X mental retardation 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP2 forkhead box P2
FRZB frizzled-related protein
FSHR follicle stimulating hormone receptor
FXR2 fragile X mental retardation, autosomal homolog 2
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD3 frizzled class receptor 3
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GBX1 gastrulation brain homeobox 1
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GDI1 GDP dissociation inhibitor 1
GIF gastric intrinsic factor (vitamin B synthesis)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJB6 gap junction protein, beta 6, 30kDa
GM2A GM2 ganglioside activator
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNAS GNAS complex locus
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GPR19 G protein-coupled receptor 19
GPR26 G protein-coupled receptor 26
GPR83 G protein-coupled receptor 83
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRID2 glutamate receptor, ionotropic, delta 2
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM1 glutamate receptor, metabotropic 1
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM8 glutamate receptor, metabotropic 8
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSTA3 glutathione S-transferase alpha 3
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCRTR1 hypocretin (orexin) receptor 1
HCRTR2 hypocretin (orexin) receptor 2
HDC histidine decarboxylase
HIPK2 homeodomain interacting protein kinase 2
HMX3 H6 family homeobox 3
HNF4G hepatocyte nuclear factor 4, gamma
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRH1 histamine receptor H1
HRH3 histamine receptor H3
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTT huntingtin
HYDIN HYDIN, axonemal central pair apparatus protein
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFT122 intraflagellar transport 122
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
INS insulin
KALRN kalirin, RhoGEF kinase
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5
KCNIP3 Kv channel interacting protein 3, calsenilin
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KDM8 lysine (K)-specific demethylase 8
KIF13A kinesin family member 13A
KIRREL3 kin of IRRE like 3 (Drosophila)
L1CAM L1 cell adhesion molecule
LAMA2 laminin, alpha 2
LPAR5 lysophosphatidic acid receptor 5
LRP5 low density lipoprotein receptor-related protein 5
LRRC7 leucine rich repeat containing 7
LRRN1 leucine rich repeat neuronal 1
LRRTM1 leucine rich repeat transmembrane neuronal 1
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing
LSAMP limbic system-associated membrane protein
LYPD1 LY6/PLAUR domain containing 1
MAGED1 melanoma antigen family D1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MAP2 microtubule-associated protein 2
MAP6 microtubule-associated protein 6
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPT microtubule-associated protein tau
MARCH9 membrane-associated ring finger (C3HC4) 9
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC5R melanocortin 5 receptor
MCHR1 melanin-concentrating hormone receptor 1
MDK midkine (neurite growth-promoting factor 2)
MECP2 methyl CpG binding protein 2
MED18 mediator complex subunit 18
MKKS McKusick-Kaufman syndrome
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MPST mercaptopyruvate sulfurtransferase
MYBPC3 myosin binding protein C, cardiac
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NAGLU N-acetylglucosaminidase, alpha
NAT8L N-acetyltransferase 8-like (GCN5-related, putative)
NAV2 neuron navigator 2
NCOR1 nuclear receptor corepressor 1
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NENF neudesin neurotrophic factor
NFASC neurofascin
NIPAL3 NIPA-like domain containing 3
NLGN3 neuroligin 3
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NPAS3 neuronal PAS domain protein 3
NPAS4 neuronal PAS domain protein 4
NPEPPS aminopeptidase puromycin sensitive
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY4R neuropeptide Y receptor Y4
NR2E1 nuclear receptor subfamily 2, group E, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NTAN1 N-terminal asparagine amidase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPA1 optic atrophy 1 (autosomal dominant)
OPHN1 oligophrenin 1
OPRD1 opioid receptor, delta 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OTC ornithine carbamoyltransferase
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARK2 parkin RBR E3 ubiquitin protein ligase
PAWR PRKC, apoptosis, WT1, regulator
PBX3 pre-B-cell leukemia homeobox 3
PCDH17 protocadherin 17
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE10A phosphodiesterase 10A
PDE1B phosphodiesterase 1B, calmodulin-dependent
PDLIM5 PDZ and LIM domain 5
PDYN prodynorphin
PENK proenkephalin
PEX5L peroxisomal biogenesis factor 5-like
PFN2 profilin 2
PITX3 paired-like homeodomain 3
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
POMC proopiomelanocortin
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPT1 palmitoyl-protein thioesterase 1
PRKCG protein kinase C, gamma
PRKCZ protein kinase C, zeta
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PSAP prosaposin
PTCH1 patched 1
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGFRN prostaglandin F2 receptor inhibitor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK7 protein tyrosine kinase 7 (inactive)
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRG protein tyrosine phosphatase, receptor type, G
QKI QKI, KH domain containing, RNA binding
RAI1 retinoic acid induced 1
RALBP1 ralA binding protein 1
RASD2 RASD family, member 2
RGS14 regulator of G-protein signaling 14
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RGS7 regulator of G-protein signaling 7
RIC1 RAB6A GEF complex partner 1
RIC8A RIC8 guanine nucleotide exchange factor A
RLN3 relaxin 3
RNF103 ring finger protein 103
RORB RAR-related orphan receptor B
RTN4R reticulon 4 receptor
RYR3 ryanodine receptor 3
S100A1 S100 calcium binding protein A1
S100A10 S100 calcium binding protein A10
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SEPT5 septin 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN3 sestrin 3
SETD1A SET domain containing 1A
SFRP2 secreted frizzled-related protein 2
SH3KBP1 SH3-domain kinase binding protein 1
SHANK1 SH3 and multiple ankyrin repeat domains 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHANK3 SH3 and multiple ankyrin repeat domains 3
SIGMAR1 sigma non-opioid intracellular receptor 1
SIRPA signal-regulatory protein alpha
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLITRK1 SLIT and NTRK-like family, member 1
SLITRK5 SLIT and NTRK-like family, member 5
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNAP25 synaptosomal-associated protein, 25kDa
SOCS7 suppressor of cytokine signaling 7
SP4 Sp4 transcription factor
SPPL3 signal peptide peptidase like 3
SPRED1 sprouty-related, EVH1 domain containing 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SRR serine racemase
SSTR2 somatostatin receptor 2
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
STON2 stonin 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STX1A syntaxin 1A (brain)
SV2C synaptic vesicle glycoprotein 2C
SYN1 synapsin I
SYN2 synapsin II
SYN3 synapsin III
SYNGAP1 synaptic Ras GTPase activating protein 1
SYNPO synaptopodin
SYTL1 synaptotagmin-like 1
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TACR3 tachykinin receptor 3
TBX1 T-box 1
TDO2 tryptophan 2,3-dioxygenase
THRA thyroid hormone receptor, alpha
TLR3 toll-like receptor 3
TMEM43 transmembrane protein 43
TNC tenascin C
TNF tumor necrosis factor
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TOM1L2 target of myb1-like 2 (chicken)
TP73 tumor protein p73
TPGS1 tubulin polyglutamylase complex subunit 1
TPH2 tryptophan hydroxylase 2
TRHR thyrotropin-releasing hormone receptor
TRIB2 tribbles pseudokinase 2
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSN translin
TUBA1A tubulin, alpha 1a
UBE3A ubiquitin protein ligase E3A
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCN urocortin
ULK2 unc-51 like autophagy activating kinase 2
USP46 ubiquitin specific peptidase 46
VAMP7 vesicle-associated membrane protein 7
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
WASF1 WAS protein family, member 1
WFS1 Wolfram syndrome 1 (wolframin)
XBP1 X-box binding protein 1
ZDHHC8 zinc finger, DHHC-type containing 8
ZEB1 zinc finger E-box binding homeobox 1
ZIC2 Zic family member 2
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF175 zinc finger protein 175