abnormal electrophysiology of sinoatrial node origin Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the sinoatrial (SA) node in the right atrium. THe SA node acts as the pacemaker of the heart. (Human Phenotype Ontology, HP_0011702)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0011702
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Genes

148 genes associated with the abnormal electrophysiology of sinoatrial node origin phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.50746
KIAA1755 KIAA1755 2.20934
CD46 CD46 molecule, complement regulatory protein 2.12345
CCDC141 coiled-coil domain containing 141 2.12345
SYT10 synaptotagmin X 2.08106
FADS1 fatty acid desaturase 1 2.05673
CHRM2 cholinergic receptor, muscarinic 2 1.5645
NKX2-5 NK2 homeobox 5 1.54733
CEP85L centrosomal protein 85kDa-like 1.49916
FNDC3B fibronectin type III domain containing 3B 1.35521
RFX4 regulatory factor X, 4 (influences HLA class II expression) 1.32793
CPNE8 copine VIII 1.29386
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.1784
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 1.12851
FAM149B1 family with sequence similarity 149, member B1 1.12773
PDE11A phosphodiesterase 11A 1.11203
CPNE5 copine V 1.05066
TMEM135 transmembrane protein 135 1.03592
PADI3 peptidyl arginine deiminase, type III 1.03536
SLC35F1 solute carrier family 35, member F1 1.01692
ACTN4 actinin, alpha 4 1.00059
CNTN5 contactin 5 0.971092
GIGYF1 GRB10 interacting GYF protein 1 0.96305
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.947793
KIAA1715 KIAA1715 0.945838
CLCNKA chloride channel, voltage-sensitive Ka 0.931762
OSBP2 oxysterol binding protein 2 0.884439
DCP1A decapping mRNA 1A 0.882984
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.882984
SMAD3 SMAD family member 3 0.870439
TMEM132D transmembrane protein 132D 0.855449
DAB2IP DAB2 interacting protein 0.855449
FABP7 fatty acid binding protein 7, brain 0.850223
CA10 carbonic anhydrase X 0.843198
EFNA5 ephrin-A5 0.841148
ARRB1 arrestin, beta 1 0.838165
PRKG1 protein kinase, cGMP-dependent, type I 0.82634
MAPK1 mitogen-activated protein kinase 1 0.823837
ZNF385D zinc finger protein 385D 0.816759
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.816759
DOCK4 dedicator of cytokinesis 4 0.808534
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.804323
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.798387
CHD6 chromodomain helicase DNA binding protein 6 0.787244
CMYA5 cardiomyopathy associated 5 0.785384
KIAA1549L KIAA1549-like 0.784773
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.782964
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.777754
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.77023
TP73 tumor protein p73 0.767696
WDR86 WD repeat domain 86 0.767198
LGALS4 lectin, galactoside-binding, soluble, 4 0.766212
CNPY3 canopy FGF signaling regulator 3 0.765174
HOMEZ homeobox and leucine zipper encoding 0.762459
LDAH lipid droplet associated hydrolase 0.758275
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.755257
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.754273
NCEH1 neutral cholesterol ester hydrolase 1 0.744097
TK1 thymidine kinase 1, soluble 0.740245
PTK2 protein tyrosine kinase 2 0.739411
MYH11 myosin, heavy chain 11, smooth muscle 0.734094
MAP2 microtubule-associated protein 2 0.734094
ANKRD33B ankyrin repeat domain 33B 0.730636
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.728954
MBD5 methyl-CpG binding domain protein 5 0.728954
ZFPM2 zinc finger protein, FOG family member 2 0.721344
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.712186
PARP12 poly (ADP-ribose) polymerase family, member 12 0.710458
VWA3B von Willebrand factor A domain containing 3B 0.692786
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.689964
EBF1 early B-cell factor 1 0.689042
SLC38A8 solute carrier family 38, member 8 0.687825
CSMD1 CUB and Sushi multiple domains 1 0.686922
RALYL RALY RNA binding protein-like 0.686028
TENM4 teneurin transmembrane protein 4 0.685142
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.679359
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.679359
MCPH1 microcephalin 1 0.677522
LAMA1 laminin, alpha 1 0.676316
KLHL21 kelch-like family member 21 0.674532
MTPN myotrophin 0.673945
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.670205
SEC31B SEC31 homolog B (S. cerevisiae) 0.667695
KLHL1 kelch-like family member 1 0.665514
TCF21 transcription factor 21 0.664442
ALK anaplastic lymphoma receptor tyrosine kinase 0.664442
TGFB2 transforming growth factor, beta 2 0.662854
LINGO2 leucine rich repeat and Ig domain containing 2 0.652159
TMEM87B transmembrane protein 87B 0.652159
ITGA1 integrin, alpha 1 0.646866
NCOA1 nuclear receptor coactivator 1 0.644641
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.640327
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.638927
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.635958
ITGA9 integrin, alpha 9 0.635733
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.635061
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.634838
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.631765
RAB40C RAB40C, member RAS oncogene family 0.631549
EML6 echinoderm microtubule associated protein like 6 0.630262
ACTA2 actin, alpha 2, smooth muscle, aorta 0.627944
SGCZ sarcoglycan, zeta 0.62629
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.62426
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.621289
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.619932
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 0.6144
SSUH2 ssu-2 homolog (C. elegans) 0.611229
LAMB1 laminin, beta 1 0.60762
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.607443
FAS Fas cell surface death receptor 0.602605
TMEM232 transmembrane protein 232 0.595915
RNLS renalase, FAD-dependent amine oxidase 0.594349
ANTXR1 anthrax toxin receptor 1 0.592807
ZNF516 zinc finger protein 516 0.590688
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.588613
CLMN calmin (calponin-like, transmembrane) 0.587592
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.587592
CPQ carboxypeptidase Q 0.587158
NCALD neurocalcin delta 0.587014
TRIM67 tripartite motif containing 67 0.586295
OPCML opioid binding protein/cell adhesion molecule-like 0.583787
DLG2 discs, large homolog 2 (Drosophila) 0.583301
GRM5 glutamate receptor, metabotropic 5 0.58318
VAV3 vav 3 guanine nucleotide exchange factor 0.582338
ACYP2 acylphosphatase 2, muscle type 0.578934
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.578819
FAXC failed axon connections homolog (Drosophila) 0.57836
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.577337
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.577111
IDE insulin-degrading enzyme 0.556012
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.556012
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.539897
SPEG SPEG complex locus 0.535942
ADORA3 adenosine A3 receptor 0.53407
FLJ37453 uncharacterized LOC729614 0.520461
CRYAB crystallin, alpha B 0.519375
CENPO centromere protein O 0.514509
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.512008
SCN10A sodium channel, voltage gated, type X alpha subunit 0.510092
NACA nascent polypeptide-associated complex alpha subunit 0.502259
PRPF3 pre-mRNA processing factor 3 0.501459
NCKIPSD NCK interacting protein with SH3 domain 0.499816
IP6K2 inositol hexakisphosphate kinase 2 0.475481
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.473207
MSI1 musashi RNA-binding protein 1 0.457258
PPP4C protein phosphatase 4, catalytic subunit 0.445034
NAE1 NEDD8 activating enzyme E1 subunit 1 0.437175
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.432689