abnormal effector t cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of a differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response (Mammalian Phenotype Ontology, MP_0002435)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002435
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Genes

383 gene mutations causing the abnormal effector t cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR4 atypical chemokine receptor 4
ACP2 acid phosphatase 2, lysosomal
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADRM1 adhesion regulating molecule 1
AFF1 AF4/FMR2 family, member 1
AKAP9 A kinase (PRKA) anchor protein 9
ANPEP alanyl (membrane) aminopeptidase
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
APOE apolipoprotein E
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARID5A AT rich interactive domain 5A (MRF1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4D ADP-ribosylation factor-like 4D
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BBC3 BCL2 binding component 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BCL6B B-cell CLL/lymphoma 6, member B
BCLAF1 BCL2-associated transcription factor 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BMF Bcl2 modifying factor
BTK Bruton agammaglobulinemia tyrosine kinase
C17ORF62 chromosome 17 open reading frame 62
C3AR1 complement component 3a receptor 1
CADM1 cell adhesion molecule 1
CARD11 caspase recruitment domain family, member 11
CBFB core-binding factor, beta subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL13 chemokine (C-C motif) ligand 13
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CD1D CD1d molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CD5 CD5 molecule
CD69 CD69 molecule
CD70 CD70 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD83 CD83 molecule
CD84 CD84 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPJ centromere protein J
CHD2 chromodomain helicase DNA binding protein 2
CHD7 chromodomain helicase DNA binding protein 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIITA class II, major histocompatibility complex, transactivator
CISH cytokine inducible SH2-containing protein
CLEC10A C-type lectin domain family 10, member A
CLEC4G C-type lectin domain family 4, member G
CLEC6A C-type lectin domain family 6, member A
COL10A1 collagen, type X, alpha 1
CORO1A coronin, actin binding protein, 1A
CRLF2 cytokine receptor-like factor 2
CRTAM cytotoxic and regulatory T cell molecule
CTSV cathepsin V
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYTIP cytohesin 1 interacting protein
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGKZ diacylglycerol kinase, zeta
DIAPH1 diaphanous-related formin 1
DLL1 delta-like 1 (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
EBAG9 estrogen receptor binding site associated, antigen, 9
EBI3 Epstein-Barr virus induced 3
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM83G family with sequence similarity 83, member G
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FBXO7 F-box protein 7
FOXN1 forkhead box N1
FOXP2 forkhead box P2
FOXP3 forkhead box P3
G6PC2 glucose-6-phosphatase, catalytic, 2
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GCLC glutamate-cysteine ligase, catalytic subunit
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPER1 G protein-coupled estrogen receptor 1
GPR15 G protein-coupled receptor 15
GPR83 G protein-coupled receptor 83
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
HAVCR1 hepatitis A virus cellular receptor 1
HAX1 HCLS1 associated protein X-1
HCST hematopoietic cell signal transducer
HELLS helicase, lymphoid-specific
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-A major histocompatibility complex, class I, A
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-G major histocompatibility complex, class I, G
HMGN5 high mobility group nucleosome binding domain 5
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like
HP1BP3 heterochromatin protein 1, binding protein 3
HTRA2 HtrA serine peptidase 2
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHM immunoglobulin heavy constant mu
IL10 interleukin 10
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL17C interleukin 17C
IL17F interleukin 17F
IL17RA interleukin 17 receptor A
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL27 interleukin 27
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
IL9R interleukin 9 receptor
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB7 integrin, beta 7
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JAK3 Janus kinase 3
KAZN kazrin, periplakin interacting protein
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA1549L KIAA1549-like
LAG3 lymphocyte-activation gene 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS9B lectin, galactoside-binding, soluble, 9B
LIG4 ligase IV, DNA, ATP-dependent
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
LY75 lymphocyte antigen 75
LY9 lymphocyte antigen 9
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MARK2 MAP/microtubule affinity-regulating kinase 2
MAVS mitochondrial antiviral signaling protein
MCL1 myeloid cell leukemia 1
MIR155 microRNA 155
MMP19 matrix metallopeptidase 19
MMP9 matrix metallopeptidase 9
MPG N-methylpurine-DNA glycosylase
MPZL2 myelin protein zero-like 2
MSI2 musashi RNA-binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYSM1 Myb-like, SWIRM and MPN domains 1
NBN nibrin
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NCR1 natural cytotoxicity triggering receptor 1
NDFIP1 Nedd4 family interacting protein 1
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NKX2-3 NK2 homeobox 3
NLRC5 NLR family, CARD domain containing 5
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP98 nucleoporin 98kDa
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAX1 paired box 1
PBX1 pre-B-cell leukemia homeobox 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PGAP3 post-GPI attachment to proteins 3
PIGR polymeric immunoglobulin receptor
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PITX3 paired-like homeodomain 3
PKNOX1 PBX/knotted 1 homeobox 1
PLA2G10 phospholipase A2, group X
PLA2G2D phospholipase A2, group IID
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PPP5C protein phosphatase 5, catalytic subunit
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT3 protein arginine methyltransferase 3
PRSS50 protease, serine, 50
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTCRA pre T-cell antigen receptor alpha
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASA3 RAS p21 protein activator 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBBP7 retinoblastoma binding protein 7
RC3H1 ring finger and CCCH-type domains 1
REG3G regenerating islet-derived 3 gamma
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFTN1 raftlin, lipid raft linker 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS3 regulator of G-protein signaling 3
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOH ras homolog family member H
RNASE10 ribonuclease, RNase A family, 10 (non-active)
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RRAS related RAS viral (r-ras) oncogene homolog
RSAD2 radical S-adenosyl methionine domain containing 2
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
RUVBL2 RuvB-like AAA ATPase 2
RXRA retinoid X receptor, alpha
S1PR1 sphingosine-1-phosphate receptor 1
SASH3 SAM and SH3 domain containing 3
SATB1 SATB homeobox 1
SCARF1 scavenger receptor class F, member 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SETD1A SET domain containing 1A
SETDB1 SET domain, bifurcated 1
SETMAR SET domain and mariner transposase fusion gene
SGMS1 sphingomyelin synthase 1
SGPL1 sphingosine-1-phosphate lyase 1
SH2D1A SH2 domain containing 1A
SHARPIN SHANK-associated RH domain interactor
SHCBP1 SHC SH2-domain binding protein 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC39A3 solute carrier family 39 (zinc transporter), member 3
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SMAD3 SMAD family member 3
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
SPNS2 spinster homolog 2 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAT4 signal transducer and activator of transcription 4
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYK spleen tyrosine kinase
SYTL1 synaptotagmin-like 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TBX21 T-box 21
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TESPA1 thymocyte expressed, positive selection associated 1
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THEMIS thymocyte selection associated
TICAM1 toll-like receptor adaptor molecule 1
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1
TMEM127 transmembrane protein 127
TMEM189 transmembrane protein 189
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNIP1 TNFAIP3 interacting protein 1
TOM1L2 target of myb1-like 2 (chicken)
TOX thymocyte selection-associated high mobility group box
TP53BP1 tumor protein p53 binding protein 1
TPP2 tripeptidyl peptidase II
TRIB2 tribbles pseudokinase 2
TSLP thymic stromal lymphopoietin
TWSG1 twisted gastrulation BMP signaling modulator 1
TXNIP thioredoxin interacting protein
UNC13D unc-13 homolog D (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
USP42 ubiquitin specific peptidase 42
VAV1 vav 1 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
WTAP Wilms tumor 1 associated protein
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZBTB7B zinc finger and BTB domain containing 7B
ZC3H12D zinc finger CCCH-type containing 12D
ZEB1 zinc finger E-box binding homeobox 1
ZNF175 zinc finger protein 175
ZNF335 zinc finger protein 335