abnormal double-positive t cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly of the subset of T cells found in the thymus that express both CD4 and CD8 (Mammalian Phenotype Ontology, MP_0002408)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002408
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Genes

125 gene mutations causing the abnormal double-positive t cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AFF1 AF4/FMR2 family, member 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ATM ATM serine/threonine kinase
BCL10 B-cell CLL/lymphoma 10
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CADM1 cell adhesion molecule 1
CBFB core-binding factor, beta subunit
CCND3 cyclin D3
CCR6 chemokine (C-C motif) receptor 6
CCR9 chemokine (C-C motif) receptor 9
CD247 CD247 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD40LG CD40 ligand
CD5 CD5 molecule
CD5L CD5 molecule-like
CD7 CD7 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD8A CD8a molecule
CD8B CD8b molecule
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CIITA class II, major histocompatibility complex, transactivator
COL10A1 collagen, type X, alpha 1
COMMD3-BMI1 COMMD3-BMI1 readthrough
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSD cathepsin D
CTSE cathepsin E
CUX1 cut-like homeobox 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F1 E2F transcription factor 1
E2F4 E2F transcription factor 4, p107/p130-binding
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EWSR1 EWS RNA-binding protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN1 forkhead box N1
FOXP3 forkhead box P3
GATA3 GATA binding protein 3
HAX1 HCLS1 associated protein X-1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HTRA2 HtrA serine peptidase 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IRF1 interferon regulatory factor 1
ITPKB inositol-trisphosphate 3-kinase B
KITLG KIT ligand
KLF13 Kruppel-like factor 13
KMT2E lysine (K)-specific methyltransferase 2E
LAMA2 laminin, alpha 2
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG4 ligase IV, DNA, ATP-dependent
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP19 matrix metallopeptidase 19
MSI2 musashi RNA-binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLK nemo-like kinase
PARL presenilin associated, rhomboid-like
PAX1 paired box 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PNP purine nucleoside phosphorylase
PRKCH protein kinase C, eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTCRA pre T-cell antigen receptor alpha
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOH ras homolog family member H
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
RUVBL2 RuvB-like AAA ATPase 2
SASH3 SAM and SH3 domain containing 3
SGPL1 sphingosine-1-phosphate lyase 1
SIRT6 sirtuin 6
SIT1 signaling threshold regulating transmembrane adaptor 1
SLA Src-like-adaptor
SLC39A3 solute carrier family 39 (zinc transporter), member 3
SPI1 Spi-1 proto-oncogene
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STK17B serine/threonine kinase 17b
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TDP2 tyrosyl-DNA phosphodiesterase 2
THEMIS thymocyte selection associated
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TPP2 tripeptidyl peptidase II
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TWSG1 twisted gastrulation BMP signaling modulator 1
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZBTB7B zinc finger and BTB domain containing 7B
ZEB1 zinc finger E-box binding homeobox 1