abnormal double-negative t cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the subset of T cells found in the thymus that express neither CD4 nor CD8 (Mammalian Phenotype Ontology, MP_0002407)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002407
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Genes

99 gene mutations causing the abnormal double-negative t cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AFF1 AF4/FMR2 family, member 1
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
BCL10 B-cell CLL/lymphoma 10
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
CARD11 caspase recruitment domain family, member 11
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNB2 cyclin B2
CCND3 cyclin D3
CD247 CD247 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD5 CD5 molecule
CDK6 cyclin-dependent kinase 6
COL10A1 collagen, type X, alpha 1
COMMD3-BMI1 COMMD3-BMI1 readthrough
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F4 E2F transcription factor 4, p107/p130-binding
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FLT3LG fms-related tyrosine kinase 3 ligand
FOXN1 forkhead box N1
GATA3 GATA binding protein 3
GFI1 growth factor independent 1 transcription repressor
GPR15 G protein-coupled receptor 15
GRAP2 GRB2-related adaptor protein 2
HAVCR1 hepatitis A virus cellular receptor 1
HELLS helicase, lymphoid-specific
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2 interleukin 2
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
KAT6A K(lysine) acetyltransferase 6A
KITLG KIT ligand
KMT2E lysine (K)-specific methyltransferase 2E
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG4 ligase IV, DNA, ATP-dependent
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
MALT1 MALT1 paracaspase
MAML1 mastermind-like 1 (Drosophila)
MAPK14 mitogen-activated protein kinase 14
MCL1 myeloid cell leukemia 1
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSI2 musashi RNA-binding protein 2
MYB v-myb avian myeloblastosis viral oncogene homolog
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NOD2 nucleotide-binding oligomerization domain containing 2
NOTCH1 notch 1
PAX1 paired box 1
PKNOX1 PBX/knotted 1 homeobox 1
PNP purine nucleoside phosphorylase
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCRA pre T-cell antigen receptor alpha
PTPRC protein tyrosine phosphatase, receptor type, C
RAD50 RAD50 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RHOH ras homolog family member H
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
SPI1 Spi-1 proto-oncogene
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBATA thymus, brain and testes associated
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF4 transcription factor 4
TET2 tet methylcytosine dioxygenase 2
TP53BP1 tumor protein p53 binding protein 1
TPP2 tripeptidyl peptidase II
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZBTB1 zinc finger and BTB domain containing 1
ZBTB7B zinc finger and BTB domain containing 7B