abnormal dorsal aorta morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation (Mammalian Phenotype Ontology, MP_0004787)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004787
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Genes

66 gene mutations causing the abnormal dorsal aorta morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVRL1 activin A receptor type II-like 1
CCM2 cerebral cavernous malformation 2
CDH5 cadherin 5, type 2 (vascular endothelium)
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DLL4 delta-like 4 (Drosophila)
ECE1 endothelin converting enzyme 1
EDNRA endothelin receptor type A
ENG endoglin
ETV2 ets variant 2
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FOXO1 forkhead box O1
HDAC7 histone deacetylase 7
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ISL1 ISL LIM homeobox 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KAT7 K(lysine) acetyltransferase 7
KDR kinase insert domain receptor
KRIT1 KRIT1, ankyrin repeat containing
LEMD3 LEM domain containing 3
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK7 mitogen-activated protein kinase 7
MED24 mediator complex subunit 24
MEF2C myocyte enhancer factor 2C
MIB1 mindbomb E3 ubiquitin protein ligase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOCD myocardin
NGFR nerve growth factor receptor
NKX2-5 NK2 homeobox 5
NOTCH1 notch 1
NRP1 neuropilin 1
PAX3 paired box 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PNPLA6 patatin-like phospholipase domain containing 6
POGLUT1 protein O-glucosyltransferase 1
PRDM1 PR domain containing 1, with ZNF domain
PTK2 protein tyrosine kinase 2
PTPRJ protein tyrosine phosphatase, receptor type, J
PXN paxillin
RASIP1 Ras interacting protein 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RDH10 retinol dehydrogenase 10 (all-trans)
SCX scleraxis basic helix-loop-helix transcription factor
SMAD2 SMAD family member 2
SMAD5 SMAD family member 5
SOX4 SRY (sex determining region Y)-box 4
STK11 serine/threonine kinase 11
T T, brachyury homolog (mouse)
TAL1 T-cell acute lymphocytic leukemia 1
TBX1 T-box 1
TDG thymine-DNA glycosylase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB2 transforming growth factor, beta 2
TLL1 tolloid-like 1
TMEM100 transmembrane protein 100
TTN titin
VEGFA vascular endothelial growth factor A
WASF2 WAS protein family, member 2
WNK1 WNK lysine deficient protein kinase 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ1 zinc finger, MIZ-type containing 1