abnormal dendritic cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity (Mammalian Phenotype Ontology, MP_0002376)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002376
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Genes

139 gene mutations causing the abnormal dendritic cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADA adenosine deaminase
ADAM17 ADAM metallopeptidase domain 17
ADORA2B adenosine A2b receptor
AHR aryl hydrocarbon receptor
APOE apolipoprotein E
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
AZI2 5-azacytidine induced 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL10 B-cell CLL/lymphoma 10
CAPG capping protein (actin filament), gelsolin-like
CARD9 caspase recruitment domain family, member 9
CCL13 chemokine (C-C motif) ligand 13
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCRL2 chemokine (C-C motif) receptor-like 2
CD1D CD1d molecule
CD200R1 CD200 receptor 1
CD274 CD274 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD68 CD68 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIITA class II, major histocompatibility complex, transactivator
CLEC7A C-type lectin domain family 7, member A
CLEC9A C-type lectin domain family 9, member A
CMKLR1 chemerin chemokine-like receptor 1
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CTSE cathepsin E
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DOCK8 dedicator of cytokinesis 8
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
F11R F11 receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLT3 fms-related tyrosine kinase 3
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FSCN1 fascin actin-bundling protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
HAVCR1 hepatitis A virus cellular receptor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HRH4 histamine receptor H4
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IDO1 indoleamine 2,3-dioxygenase 1
IFIH1 interferon induced with helicase C domain 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNG interferon, gamma
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL21R interleukin 21 receptor
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL6ST interleukin 6 signal transducer
JAK3 Janus kinase 3
LGALS3 lectin, galactoside-binding, soluble, 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LPAR2 lysophosphatidic acid receptor 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MALT1 MALT1 paracaspase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MARCO macrophage receptor with collagenous structure
MAVS mitochondrial antiviral signaling protein
MB21D1 Mab-21 domain containing 1
MIR155 microRNA 155
MITF microphthalmia-associated transcription factor
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP9 matrix metallopeptidase 9
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP10 NLR family, pyrin domain containing 10
NLRP3 NLR family, pyrin domain containing 3
NRP1 neuropilin 1
OXSR1 oxidative stress responsive 1
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PDCD1LG2 programmed cell death 1 ligand 2
PELI3 pellino E3 ubiquitin protein ligase family member 3
PLA2G2D phospholipase A2, group IID
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLXNA1 plexin A1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTX3 pentraxin 3, long
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS1 regulator of G-protein signaling 1
RHBDD3 rhomboid domain containing 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUNX3 runt-related transcription factor 3
RXRA retinoid X receptor, alpha
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCARF1 scavenger receptor class F, member 1
SELL selectin L
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIRPA signal-regulatory protein alpha
SKAP2 src kinase associated phosphoprotein 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK4 serine/threonine kinase 4
SUCNR1 succinate receptor 1
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TICAM1 toll-like receptor adaptor molecule 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR5 toll-like receptor 5
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TMEM173 transmembrane protein 173
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRAF4 TNF receptor-associated factor 4
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUB tubby bipartite transcription factor
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
VAMP8 vesicle-associated membrane protein 8
WAS Wiskott-Aldrich syndrome
XCR1 chemokine (C motif) receptor 1
XPA xeroderma pigmentosum, complementation group A
ZBTB46 zinc finger and BTB domain containing 46