abnormal dendritic cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation (Mammalian Phenotype Ontology, MP_0008125)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008125
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Genes

68 gene mutations causing the abnormal dendritic cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADA adenosine deaminase
AIRE autoimmune regulator
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL3 B-cell CLL/lymphoma 3
CAMP cathelicidin antimicrobial peptide
CCL13 chemokine (C-C motif) ligand 13
CCR7 chemokine (C-C motif) receptor 7
CD207 CD207 molecule, langerin
CIITA class II, major histocompatibility complex, transactivator
CLEC10A C-type lectin domain family 10, member A
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CX3CR1 chemokine (C-X3-C motif) receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
GPR183 G protein-coupled receptor 183
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL15 interleukin 15
IL18 interleukin 18
IL1RN interleukin 1 receptor antagonist
IL2RG interleukin 2 receptor, gamma
IL34 interleukin 34
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF4 interferon regulatory factor 4
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB6 integrin, beta 6
JAK3 Janus kinase 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAVS mitochondrial antiviral signaling protein
MMP9 matrix metallopeptidase 9
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRP10 NLR family, pyrin domain containing 10
PLA2G2D phospholipase A2, group IID
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RUNX3 runt-related transcription factor 3
SPP1 secreted phosphoprotein 1
SPPL2A signal peptide peptidase like 2A
STAT2 signal transducer and activator of transcription 2, 113kDa
STK4 serine/threonine kinase 4
TCF3 transcription factor 3
TGFB1 transforming growth factor, beta 1
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRAF3IP2 TRAF3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TYROBP TYRO protein tyrosine kinase binding protein
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
XCL1 chemokine (C motif) ligand 1
XCR1 chemokine (C motif) receptor 1
ZBTB46 zinc finger and BTB domain containing 46