abnormal decidualization Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description atypical cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation; this process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta; expected changes include the eosinophilic proliferation around arterioles after ovulation or progesterone action on endometrium which increases glandular epithelial secretion, stimulates glycogen accumulation in stromal cell cytoplasm, and promotes stromal vascularity (spiral arterioles) and edema (Mammalian Phenotype Ontology, MP_0003845)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003845
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Genes

12 gene mutations causing the abnormal decidualization phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FGFR2 fibroblast growth factor receptor 2
FKBP4 FK506 binding protein 4, 59kDa
HMX3 H6 family homeobox 3
IL11RA interleukin 11 receptor, alpha
IL15 interleukin 15
NCOA1 nuclear receptor coactivator 1
PGR progesterone receptor
PRLR prolactin receptor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
WNT6 wingless-type MMTV integration site family, member 6