abnormal cranial neural crest cell migration Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage (Mammalian Phenotype Ontology, MP_0012757)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012757
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Genes

5 gene mutations causing the abnormal cranial neural crest cell migration phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
EFNB1 ephrin-B1
EFNB2 ephrin-B2
HOXA1 homeobox A1
TCOF1 Treacher Collins-Franceschetti syndrome 1
ZEB2 zinc finger E-box binding homeobox 2