abnormal cochlear hair bundle ankle links morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly in the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down; in the mouse, ankle links are only a transient feature of the developing cochlear hair bundles, present predominantly from P2 though P9, but are absent by P12; ankle links are disrupted by treatment of hair cells with EGTA and subtilisin but not by La3+ and elastase (Mammalian Phenotype Ontology, MP_0004581)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004581
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2 gene mutations causing the abnormal cochlear hair bundle ankle links morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRV1 adhesion G protein-coupled receptor V1
MYO7A myosin VIIA