abnormal circulating interleukin-6 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts (Mammalian Phenotype Ontology, MP_0008595)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008595
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Genes

99 gene mutations causing the abnormal circulating interleukin-6 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ARID5A AT rich interactive domain 5A (MRF1-like)
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BAG4 BCL2-associated athanogene 4
BBS12 Bardet-Biedl syndrome 12
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5AR1 complement component 5a receptor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD14 CD14 molecule
CD19 CD19 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLIC4 chloride intracellular channel 4
CRH corticotropin releasing hormone
CTSC cathepsin C
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR2 chemokine (C-X-C motif) receptor 2
DUSP1 dual specificity phosphatase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN1 forkhead box N1
FOXP3 forkhead box P3
HSPB8 heat shock 22kDa protein 8
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
ING4 inhibitor of growth family, member 4
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LEPR leptin receptor
LIF leukemia inhibitory factor
LRRC4C leucine rich repeat containing 4C
LYN LYN proto-oncogene, Src family tyrosine kinase
MAVS mitochondrial antiviral signaling protein
MC4R melanocortin 4 receptor
MEFV Mediterranean fever
MEP1A meprin A, alpha (PABA peptide hydrolase)
MIR122 microRNA 122
MYD88 myeloid differentiation primary response 88
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRC3 NLR family, CARD domain containing 3
NLRP3 NLR family, pyrin domain containing 3
NLRX1 NLR family member X1
NMU neuromedin U
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PGLYRP2 peptidoglycan recognition protein 2
PILRB paired immunoglobin-like type 2 receptor beta
POMC proopiomelanocortin
PRF1 perforin 1 (pore forming protein)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB27A RAB27A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RHBDD3 rhomboid domain containing 3
SCARB1 scavenger receptor class B, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIRT3 sirtuin 3
SMAD3 SMAD family member 3
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPP1 secreted phosphoprotein 1
STX11 syntaxin 11
TBC1D23 TBC1 domain family, member 23
TBK1 TANK-binding kinase 1
THBD thrombomodulin
TICAM1 toll-like receptor adaptor molecule 1
TLR4 toll-like receptor 4
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOLLIP toll interacting protein
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAFD1 TRAF-type zinc finger domain containing 1
TXNDC2 thioredoxin domain containing 2 (spermatozoa)
UNC93B1 unc-93 homolog B1 (C. elegans)
USP18 ubiquitin specific peptidase 18