abnormal circulating interleukin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli (Mammalian Phenotype Ontology, MP_0008588)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008588
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Genes

176 gene mutations causing the abnormal circulating interleukin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
AIM2 absent in melanoma 2
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID5A AT rich interactive domain 5A (MRF1-like)
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BAG4 BCL2-associated athanogene 4
BBS12 Bardet-Biedl syndrome 12
BRD2 bromodomain containing 2
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5AR1 complement component 5a receptor 1
CARD11 caspase recruitment domain family, member 11
CASP12 caspase 12 (gene/pseudogene)
CASP4 caspase 4, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CCR3 chemokine (C-C motif) receptor 3
CD14 CD14 molecule
CD19 CD19 molecule
CD28 CD28 molecule
CD44 CD44 molecule (Indian blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC7A C-type lectin domain family 7, member A
CLIC4 chloride intracellular channel 4
CRH corticotropin releasing hormone
CTSC cathepsin C
CTSE cathepsin E
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR2 chemokine (C-X-C motif) receptor 2
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DUSP1 dual specificity phosphatase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN1 forkhead box N1
FOXP3 forkhead box P3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GBP5 guanylate binding protein 5
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HEXB hexosaminidase B (beta polypeptide)
HSPB8 heat shock 22kDa protein 8
ICOS inducible T-cell co-stimulator
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12A interleukin 12A
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL22 interleukin 22
IL27 interleukin 27
IL27RA interleukin 27 receptor, alpha
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
ING4 inhibitor of growth family, member 4
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT1 keratin 1, type II
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LRRC4C leucine rich repeat containing 4C
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAVS mitochondrial antiviral signaling protein
MC4R melanocortin 4 receptor
MEFV Mediterranean fever
MEP1A meprin A, alpha (PABA peptide hydrolase)
MINA MYC induced nuclear antigen
MIR122 microRNA 122
MMP9 matrix metallopeptidase 9
MTA2 metastasis associated 1 family, member 2
MYD88 myeloid differentiation primary response 88
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRC3 NLR family, CARD domain containing 3
NLRP3 NLR family, pyrin domain containing 3
NLRP6 NLR family, pyrin domain containing 6
NLRX1 NLR family member X1
NMU neuromedin U
NOD2 nucleotide-binding oligomerization domain containing 2
NPY1R neuropeptide Y receptor Y1
OLFM4 olfactomedin 4
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OSMR oncostatin M receptor
PARP1 poly (ADP-ribose) polymerase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PGLYRP2 peptidoglycan recognition protein 2
PILRB paired immunoglobin-like type 2 receptor beta
PLCD1 phospholipase C, delta 1
POMC proopiomelanocortin
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRF1 perforin 1 (pore forming protein)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCE protein kinase C, epsilon
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYCARD PYD and CARD domain containing
RAB27A RAB27A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDD3 rhomboid domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCARB1 scavenger receptor class B, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIRT3 sirtuin 3
SLAMF6 SLAM family member 6
SMAD3 SMAD family member 3
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOCS2 suppressor of cytokine signaling 2
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STX11 syntaxin 11
TBC1D23 TBC1 domain family, member 23
TBK1 TANK-binding kinase 1
THBD thrombomodulin
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR8 toll-like receptor 8
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOLLIP toll interacting protein
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAFD1 TRAF-type zinc finger domain containing 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSLP thymic stromal lymphopoietin
TXNDC2 thioredoxin domain containing 2 (spermatozoa)
TYK2 tyrosine kinase 2
UNC93B1 unc-93 homolog B1 (C. elegans)
USP18 ubiquitin specific peptidase 18