abnormal circulating interferon level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the amount in the blood of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions (Mammalian Phenotype Ontology, MP_0008548)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008548
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Genes

74 gene mutations causing the abnormal circulating interferon level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAR adenosine deaminase, RNA-specific
ATF2 activating transcription factor 2
BCL2L12 BCL2-like 12 (proline rich)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CD19 CD19 molecule
CD28 CD28 molecule
CD44 CD44 molecule (Indian blood group)
CXCL16 chemokine (C-X-C motif) ligand 16
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DUSP1 dual specificity phosphatase 1
FLT3 fms-related tyrosine kinase 3
FOXP3 forkhead box P3
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR183 G protein-coupled receptor 183
ICOS inducible T-cell co-stimulator
IFNB1 interferon, beta 1, fibroblast
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL18 interleukin 18
IL2 interleukin 2
IL27RA interleukin 27 receptor, alpha
IL4R interleukin 4 receptor
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTA lymphotoxin alpha
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAVS mitochondrial antiviral signaling protein
MB21D1 Mab-21 domain containing 1
MINA MYC induced nuclear antigen
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
MTA2 metastasis associated 1 family, member 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NFIL3 nuclear factor, interleukin 3 regulated
NOD2 nucleotide-binding oligomerization domain containing 2
OASL 2'-5'-oligoadenylate synthetase-like
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PILRB paired immunoglobin-like type 2 receptor beta
PRF1 perforin 1 (pore forming protein)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB27A RAB27A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RHBDD3 rhomboid domain containing 3
RSAD2 radical S-adenosyl methionine domain containing 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SIRT3 sirtuin 3
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STX11 syntaxin 11
TICAM1 toll-like receptor adaptor molecule 1
TLR7 toll-like receptor 7
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TP53 tumor protein p53
TRPM2 transient receptor potential cation channel, subfamily M, member 2
UNC93B1 unc-93 homolog B1 (C. elegans)
USP18 ubiquitin specific peptidase 18
USP21 ubiquitin specific peptidase 21
VAV1 vav 1 guanine nucleotide exchange factor