abnormal circulating insulin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the blood concentration of the polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids (Mammalian Phenotype Ontology, MP_0001560)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001560
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Genes

318 gene mutations causing the abnormal circulating insulin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACTB actin, beta
ADCY3 adenylate cyclase 3
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA1B adrenoceptor alpha 1B
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
AKAP5 A kinase (PRKA) anchor protein 5
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALMS1 Alstrom syndrome protein 1
ALX3 ALX homeobox 3
ANGPTL6 angiopoietin-like 6
ANKRD26 ankyrin repeat domain 26
ANXA1 annexin A1
APOA2 apolipoprotein A-II
AQP7 aquaporin 7
ARRDC3 arrestin domain containing 3
ASIP agouti signaling protein
ATF4 activating transcription factor 4
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATXN2 ataxin 2
AZIN2 antizyme inhibitor 2
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BBS4 Bardet-Biedl syndrome 4
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BDNF brain-derived neurotrophic factor
BGLAP bone gamma-carboxyglutamate (gla) protein
BRD2 bromodomain containing 2
BRS3 bombesin-like receptor 3
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C3 complement component 3
C5AR2 complement component 5a receptor 2
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CARTPT CART prepropeptide
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CCDC80 coiled-coil domain containing 80
CCL13 chemokine (C-C motif) ligand 13
CD38 CD38 molecule
CDK4 cyclin-dependent kinase 4
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CERS6 ceramide synthase 6
CHD7 chromodomain helicase DNA binding protein 7
CHRM3 cholinergic receptor, muscarinic 3
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
COL5A3 collagen, type V, alpha 3
CPE carboxypeptidase E
CPT1C carnitine palmitoyltransferase 1C
CRBN cereblon
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRTC1 CREB regulated transcription coactivator 1
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTF1 cardiotrophin 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R4 cytochrome b5 reductase 4
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPP4 dipeptidyl-peptidase 4
E2F1 E2F transcription factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ERCC1 excision repair cross-complementation group 1
FABP1 fatty acid binding protein 1, liver
FABP2 fatty acid binding protein 2, intestinal
FABP4 fatty acid binding protein 4, adipocyte
FAM3B family with sequence similarity 3, member B
FFAR1 free fatty acid receptor 1
FFAR2 free fatty acid receptor 2
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FOXA1 forkhead box A1
FOXO1 forkhead box O1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FTO fat mass and obesity associated
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GAST gastrin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCG glucagon
GCGR glucagon receptor
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GHRL ghrelin/obestatin prepropeptide
GIPR gastric inhibitory polypeptide receptor
GLIS3 GLIS family zinc finger 3
GLP1R glucagon-like peptide 1 receptor
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAS GNAS complex locus
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPBAR1 G protein-coupled bile acid receptor 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR26 G protein-coupled receptor 26
GPR39 G protein-coupled receptor 39
GPR68 G protein-coupled receptor 68
GPRC6A G protein-coupled receptor, class C, group 6, member A
GSK3B glycogen synthase kinase 3 beta
GUCY2C guanylate cyclase 2C
GYS2 glycogen synthase 2 (liver)
HADH hydroxyacyl-CoA dehydrogenase
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HDC histidine decarboxylase
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HMGA1 high mobility group AT-hook 1
HMGN3 high mobility group nucleosomal binding domain 3
HNF1A HNF1 homeobox A
HRH1 histamine receptor H1
HRH3 histamine receptor H3
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IAPP islet amyloid polypeptide
IDE insulin-degrading enzyme
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL1R1 interleukin 1 receptor, type I
ILDR2 immunoglobulin-like domain containing receptor 2
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSL5 insulin-like 5
INSR insulin receptor
IP6K1 inositol hexakisphosphate kinase 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KDM3A lysine (K)-specific demethylase 3A
KL klotho
KLB klotho beta
KMT2B lysine (K)-specific methyltransferase 2B
KPTN kaptin (actin binding protein)
LCLAT1 lysocardiolipin acyltransferase 1
LCMT1 leucine carboxyl methyltransferase 1
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGALS12 lectin, galactoside-binding, soluble, 12
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LPIN1 lipin 1
LRP5 low density lipoprotein receptor-related protein 5
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAPK13 mitogen-activated protein kinase 13
MAPK8 mitogen-activated protein kinase 8
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD5 methyl-CpG binding domain protein 5
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
MEN1 multiple endocrine neoplasia I
MGAM maltase-glucoamylase
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGLL monoglyceride lipase
MIER1 mesoderm induction early response 1, transcriptional regulator
MIR184 microRNA 184
MLXIPL MLX interacting protein-like
MOGAT2 monoacylglycerol O-acyltransferase 2
MRAP2 melanocortin 2 receptor accessory protein 2
MSTN myostatin
MYO7A myosin VIIA
NCOA3 nuclear receptor coactivator 3
NCOR2 nuclear receptor corepressor 2
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NMU neuromedin U
NOS3 nitric oxide synthase 3 (endothelial cell)
NPBWR1 neuropeptides B/W receptor 1
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OCA2 oculocutaneous albinism II
OMA1 OMA1 zinc metallopeptidase
ONECUT1 one cut homeobox 1
OPRM1 opioid receptor, mu 1
OSMR oncostatin M receptor
PASK PAS domain containing serine/threonine kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDE10A phosphodiesterase 10A
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDPK1 3-phosphoinositide dependent protein kinase 1
PDX1 pancreatic and duodenal homeobox 1
PFKM phosphofructokinase, muscle
PGR progesterone receptor
PHOX2A paired-like homeobox 2a
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PITPNA phosphatidylinositol transfer protein, alpha
PLA2G1B phospholipase A2, group IB (pancreas)
PLIN1 perilipin 1
PNLIP pancreatic lipase
PNPLA2 patatin-like phospholipase domain containing 2
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PROX1 prospero homeobox 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTRF polymerase I and transcript release factor
PTTG1 pituitary tumor-transforming 1
PYY peptide YY
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBM4 RNA binding motif protein 4
RIMS2 regulating synaptic membrane exocytosis 2
RLN3 relaxin 3
RPS6 ribosomal protein S6
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SDC3 syndecan 3
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERTAD2 SERTA domain containing 2
SGMS1 sphingomyelin synthase 1
SH2B2 SH2B adaptor protein 2
SIDT2 SID1 transmembrane family, member 2
SIK3 SIK family kinase 3
SIM1 single-minded family bHLH transcription factor 1
SIRT1 sirtuin 1
SIRT3 sirtuin 3
SIRT6 sirtuin 6
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
SNX5 sorting nexin 5
SOCS2 suppressor of cytokine signaling 2
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SRA1 steroid receptor RNA activator 1
SSFA2 sperm specific antigen 2
SST somatostatin
SSTR5 somatostatin receptor 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STEAP4 STEAP family member 4
STX4 syntaxin 4
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D4 TBC1 domain family, member 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TERF2IP telomeric repeat binding factor 2, interacting protein
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
THRA thyroid hormone receptor, alpha
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TMEM189 transmembrane protein 189
TNF tumor necrosis factor
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRH thyrotropin-releasing hormone
TUB tubby bipartite transcription factor
TXNIP thioredoxin interacting protein
TYK2 tyrosine kinase 2
UCN3 urocortin 3
USH1C Usher syndrome 1C (autosomal recessive, severe)
VGF VGF nerve growth factor inducible
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WRN Werner syndrome, RecQ helicase-like
ZBTB20 zinc finger and BTB domain containing 20
ZEB1 zinc finger E-box binding homeobox 1