abnormal circulating gonadotropin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis (Mammalian Phenotype Ontology, MP_0003361)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003361
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Genes

77 gene mutations causing the abnormal circulating gonadotropin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADRA1B adrenoceptor alpha 1B
ADRM1 adhesion regulating molecule 1
AFP alpha-fetoprotein
AMH anti-Mullerian hormone
AR androgen receptor
BCL2L2 BCL2-like 2
BGLAP bone gamma-carboxyglutamate (gla) protein
CDK4 cyclin-dependent kinase 4
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CGA glycoprotein hormones, alpha polypeptide
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLOCK clock circadian regulator
CORT cortistatin
CRTC1 CREB regulated transcription coactivator 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DHH desert hedgehog
DRD2 dopamine receptor D2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FANCL Fanconi anemia, complementation group L
FOXN1 forkhead box N1
FOXO3 forkhead box O3
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GDF9 growth differentiation factor 9
GHR growth hormone receptor
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GPR3 G protein-coupled receptor 3
INHA inhibin, alpha
INHBA inhibin, beta A
INHBB inhibin, beta B
IRS2 insulin receptor substrate 2
JUND jun D proto-oncogene
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAMA2 laminin, alpha 2
LATS1 large tumor suppressor kinase 1
LHCGR luteinizing hormone/choriogonadotropin receptor
LHX3 LIM homeobox 3
LHX9 LIM homeobox 9
LIN28A lin-28 homolog A (C. elegans)
MARK2 MAP/microtubule affinity-regulating kinase 2
MRC1 mannose receptor, C type 1
NHLH2 nescient helix loop helix 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NPC1 Niemann-Pick disease, type C1
NPEPPS aminopeptidase puromycin sensitive
NR1H3 nuclear receptor subfamily 1, group H, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OTX2 orthodenticle homeobox 2
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PGR progesterone receptor
PLK4 polo-like kinase 4
POU1F1 POU class 1 homeobox 1
PRL prolactin
PRLR prolactin receptor
PROP1 PROP paired-like homeobox 1
PSEN1 presenilin 1
PTDSS2 phosphatidylserine synthase 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SIRT1 sirtuin 1
SIX5 SIX homeobox 5
SOD1 superoxide dismutase 1, soluble
SST somatostatin
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TRHR thyrotropin-releasing hormone receptor
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIP vasoactive intestinal peptide
XPA xeroderma pigmentosum, complementation group A