abnormal chromosome number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description chromosome count is other than the expected diploid chromosome number (Mammalian Phenotype Ontology, MP_0004023)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004023
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Genes

59 gene mutations causing the abnormal chromosome number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APC adenomatous polyposis coli
ATAD5 ATPase family, AAA domain containing 5
AURKA aurora kinase A
AURKB aurora kinase B
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPA centromere protein A
CHEK2 checkpoint kinase 2
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DIDO1 death inducer-obliterator 1
DNA2 DNA replication helicase/nuclease 2
DOT1L DOT1-like histone H3K79 methyltransferase
ERCC1 excision repair cross-complementation group 1
FUS FUS RNA binding protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA1 GATA binding protein 1 (globin transcription factor 1)
H3F3A H3 histone, family 3A
HELLS helicase, lymphoid-specific
HORMAD1 HORMA domain containing 1
LATS2 large tumor suppressor kinase 2
LMNA lamin A/C
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBD1 methyl-CpG binding domain protein 1
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
NEK7 NIMA-related kinase 7
PDS5B PDS5 cohesin associated factor B
PELO pelota homolog (Drosophila)
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAE1 ribonucleic acid export 1
RB1 retinoblastoma 1
RECQL RecQ helicase-like
RGPD1 RANBP2-like and GRIP domain containing 1
SGOL1 shugoshin-like 1 (S. pombe)
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SPI1 Spi-1 proto-oncogene
STAG1 stromal antigen 1
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
TERT telomerase reverse transcriptase
TOP3B topoisomerase (DNA) III beta
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TRIM24 tripartite motif containing 24
USP44 ubiquitin specific peptidase 44