abnormal cell nucleus morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated; in most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing, but in some species, or in specialized cell types, RNA metabolism or DNA replication may be absent (Mammalian Phenotype Ontology, MP_0003111)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003111
Similar Terms
Downloads & Tools

Genes

128 gene mutations causing the abnormal cell nucleus morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APC adenomatous polyposis coli
ARHGAP1 Rho GTPase activating protein 1
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDX2 caudal type homeobox 2
CENPA centromere protein A
CENPC centromere protein C
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
COIL coilin
CTC1 CTS telomere maintenance complex component 1
CTNND1 catenin (cadherin-associated protein), delta 1
DAXX death-domain associated protein
DCLRE1A DNA cross-link repair 1A
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DIDO1 death inducer-obliterator 1
DKC1 dyskeratosis congenita 1, dyskerin
DNA2 DNA replication helicase/nuclease 2
DNASE1L2 deoxyribonuclease I-like 2
DOT1L DOT1-like histone H3K79 methyltransferase
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC1 excision repair cross-complementation group 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EWSR1 EWS RNA-binding protein 1
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FMR1 fragile X mental retardation 1
FUS FUS RNA binding protein
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA1 GATA binding protein 1 (globin transcription factor 1)
GLRX3 glutaredoxin 3
GMCL1 germ cell-less, spermatogenesis associated 1
GMNN geminin, DNA replication inhibitor
H3F3A H3 histone, family 3A
HELLS helicase, lymphoid-specific
HORMAD1 HORMA domain containing 1
HTT huntingtin
HUS1 HUS1 checkpoint homolog (S. pombe)
KAT6A K(lysine) acetyltransferase 6A
KAT8 K(lysine) acetyltransferase 8
KIF22 kinesin family member 22
LATS2 large tumor suppressor kinase 2
LBR lamin B receptor
LEMD3 LEM domain containing 3
LMNA lamin A/C
LMNB1 lamin B1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBD1 methyl-CpG binding domain protein 1
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MCPH1 microcephalin 1
MECP2 methyl CpG binding protein 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEK7 NIMA-related kinase 7
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
PDS5B PDS5 cohesin associated factor B
PELO pelota homolog (Drosophila)
PIF1 PIF1 5'-to-3' DNA helicase
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POT1 protection of telomeres 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAD21L1 RAD21-like 1 (S. pombe)
RAD54L RAD54-like (S. cerevisiae)
RAE1 ribonucleic acid export 1
RB1 retinoblastoma 1
RBM19 RNA binding motif protein 19
RECQL RecQ helicase-like
RGPD1 RANBP2-like and GRIP domain containing 1
RPL38 ribosomal protein L38
RTEL1 regulator of telomere elongation helicase 1
SGOL1 shugoshin-like 1 (S. pombe)
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLX4 SLX4 structure-specific endonuclease subunit
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPI1 Spi-1 proto-oncogene
STAG1 stromal antigen 1
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
SUMO1 small ubiquitin-like modifier 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TDP2 tyrosyl-DNA phosphodiesterase 2
TERC telomerase RNA component
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TERT telomerase reverse transcriptase
TGFBI transforming growth factor, beta-induced, 68kDa
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TOP3B topoisomerase (DNA) III beta
TOR1A torsin family 1, member A (torsin A)
TOR1AIP1 torsin A interacting protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TRIM24 tripartite motif containing 24
TTYH1 tweety family member 1
TYR tyrosinase
USP44 ubiquitin specific peptidase 44
ZMPSTE24 zinc metallopeptidase STE24
ZPR1 ZPR1 zinc finger