abnormal cell migration Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the movement of cells from one site to another, often occurring during developmental or chemotactic processes (Mammalian Phenotype Ontology, MP_0003091)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003091
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Genes

373 gene mutations causing the abnormal cell migration phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTN4 actinin, alpha 4
ADAM17 ADAM metallopeptidase domain 17
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADGRG1 adhesion G protein-coupled receptor G1
ADORA2B adenosine A2b receptor
AGER advanced glycosylation end product-specific receptor
AJUBA ajuba LIM protein
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5 arachidonate 5-lipoxygenase
AMOT angiomotin
ANGPTL2 angiopoietin-like 2
AOC3 amine oxidase, copper containing 3
APAF1 apoptotic peptidase activating factor 1
APC2 adenomatosis polyposis coli 2
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARID5B AT rich interactive domain 5B (MRF1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARX aristaless related homeobox
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
ASTN1 astrotactin 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BRCA1 breast cancer 1, early onset
CADPS2 Ca++-dependent secretion activator 2
CALR calreticulin
CAMP cathelicidin antimicrobial peptide
CAPG capping protein (actin filament), gelsolin-like
CAPN1 calpain 1, (mu/I) large subunit
CAPNS1 calpain, small subunit 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC88A coiled-coil domain containing 88A
CCKAR cholecystokinin A receptor
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CCR10 chemokine (C-C motif) receptor 10
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CCRL2 chemokine (C-C motif) receptor-like 2
CD151 CD151 molecule (Raph blood group)
CD22 CD22 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD69 CD69 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CEND1 cell cycle exit and neuronal differentiation 1
CFL1 cofilin 1 (non-muscle)
CHD7 chromodomain helicase DNA binding protein 7
CHRD chordin
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CLASP2 cytoplasmic linker associated protein 2
CLIC4 chloride intracellular channel 4
CMKLR1 chemerin chemokine-like receptor 1
CNN2 calponin 2
CNTNAP2 contactin associated protein-like 2
CORO1A coronin, actin binding protein, 1A
CRMP1 collapsin response mediator protein 1
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSPG4 chondroitin sulfate proteoglycan 4
CTSC cathepsin C
CTTN cortactin
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CYLD cylindromatosis (turban tumor syndrome)
CYTIP cytohesin 1 interacting protein
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DACT2 dishevelled-binding antagonist of beta-catenin 2
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DGCR8 DGCR8 microprocessor complex subunit
DIAPH1 diaphanous-related formin 1
DLC1 DLC1 Rho GTPase activating protein
DOCK1 dedicator of cytokinesis 1
DOCK2 dedicator of cytokinesis 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
ECSCR endothelial cell surface expressed chemotaxis and apoptosis regulator
EDIL3 EGF-like repeats and discoidin I-like domains 3
EDNRB endothelin receptor type B
EFNA5 ephrin-A5
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EGR2 early growth response 2
EHD1 EH-domain containing 1
EN1 engrailed homeobox 1
EPPK1 epiplakin 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESAM endothelial cell adhesion molecule
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FBXO45 F-box protein 45
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FEZF1 FEZ family zinc finger 1
FFAR2 free fatty acid receptor 2
FGF13 fibroblast growth factor 13
FGF2 fibroblast growth factor 2 (basic)
FGF6 fibroblast growth factor 6
FGFR1 fibroblast growth factor receptor 1
FKRP fukutin related protein
FKTN fukutin
FLNB filamin B, beta
FLOT1 flotillin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FLT1 fms-related tyrosine kinase 1
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
FOXC1 forkhead box C1
FOXD3 forkhead box D3
FPR1 formyl peptide receptor 1
FPR2 formyl peptide receptor 2
FSCN1 fascin actin-bundling protein 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAB1 GRB2-associated binding protein 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GBX2 gastrulation brain homeobox 2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDF3 growth differentiation factor 3
GFRA3 GDNF family receptor alpha 3
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLB1 galactosidase, beta 1
GLI3 GLI family zinc finger 3
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNPAT glyceronephosphate O-acyltransferase
GPR132 G protein-coupled receptor 132
GPR34 G protein-coupled receptor 34
GPSM3 G-protein signaling modulator 3
GSN gelsolin
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXA1 homeobox A1
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
IL4R interleukin 4 receptor
IL6 interleukin 6
ILK integrin-linked kinase
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGA8 integrin, alpha 8
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB7 integrin, beta 7
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KAT6B K(lysine) acetyltransferase 6B
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KIF14 kinesin family member 14
KIF2A kinesin heavy chain member 2A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
LBX1 ladybird homeobox 1
LGALS3 lectin, galactoside-binding, soluble, 3
LHX5 LIM homeobox 5
LHX6 LIM homeobox 6
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LITAF lipopolysaccharide-induced TNF factor
LMNB1 lamin B1
LMNB2 lamin B2
LMX1A LIM homeobox transcription factor 1, alpha
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LSP1 lymphocyte-specific protein 1
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARCO macrophage receptor with collagenous structure
MBOAT7 membrane bound O-acyltransferase domain containing 7
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1
MDK midkine (neurite growth-promoting factor 2)
MED12 mediator complex subunit 12
MET MET proto-oncogene, receptor tyrosine kinase
MMP28 matrix metallopeptidase 28
MMP7 matrix metallopeptidase 7
MPP1 membrane protein, palmitoylated 1, 55kDa
MPZ myelin protein zero
MRC2 mannose receptor, C type 2
MTSS1 metastasis suppressor 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MYF5 myogenic factor 5
MYH10 myosin, heavy chain 10, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYO1F myosin IF
MYO9B myosin IXB
NCKAP1 NCK-associated protein 1
NCKAP1L NCK-associated protein 1-like
NCKIPSD NCK interacting protein with SH3 domain
NCOA3 nuclear receptor coactivator 3
NDE1 nudE neurodevelopment protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEUROG2 neurogenin 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NINJ1 ninjurin 1
NKX2-3 NK2 homeobox 3
NLRP12 NLR family, pyrin domain containing 12
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPR1 natriuretic peptide receptor 1
NRG1 neuregulin 1
NRP1 neuropilin 1
NRP2 neuropilin 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLIG2 oligodendrocyte lineage transcription factor 2
OLIG3 oligodendrocyte transcription factor 3
OTULIN OTU deubiquitinase with linear linkage specificity
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PALLD palladin, cytoskeletal associated protein
PARP1 poly (ADP-ribose) polymerase 1
PAX3 paired box 3
PAX5 paired box 5
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PEX7 peroxisomal biogenesis factor 7
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHOX2B paired-like homeobox 2b
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PILRA paired immunoglobin-like type 2 receptor alpha
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITX2 paired-like homeodomain 2
PLA2G10 phospholipase A2, group X
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEC plectin
PLXNA2 plexin A2
PLXNB2 plexin B2
PLXNC1 plexin C1
PLXND1 plexin D1
POMK protein-O-mannose kinase
PON2 paraoxonase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PRDM1 PR domain containing 1, with ZNF domain
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRICKLE1 prickle homolog 1 (Drosophila)
PSEN1 presenilin 1
PTGES prostaglandin E synthase
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAP1A RAP1A, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RASGRP4 RAS guanyl releasing protein 4
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RAX retina and anterior neural fold homeobox
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELN reelin
RET ret proto-oncogene
RHOB ras homolog family member B
RIPPLY3 ripply transcriptional repressor 3
RNF7 ring finger protein 7
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
S100A4 S100 calcium binding protein A4
S100A9 S100 calcium binding protein A9
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
SCHIP1 schwannomin interacting protein 1
SDC4 syndecan 4
SDCCAG8 serologically defined colon cancer antigen 8
SELE selectin E
SELK selenoprotein K
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SGPL1 sphingosine-1-phosphate lyase 1
SH2D3C SH2 domain containing 3C
SIM1 single-minded family bHLH transcription factor 1
SIX1 SIX homeobox 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMAD3 SMAD family member 3
SNAI1 snail family zinc finger 1
SORBS3 sorbin and SH3 domain containing 3
SOX1 SRY (sex determining region Y)-box 1
SOX10 SRY (sex determining region Y)-box 10
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPP1 secreted phosphoprotein 1
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK25 serine/threonine kinase 25
STK4 serine/threonine kinase 4
SYNE2 spectrin repeat containing, nuclear envelope 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBX1 T-box 1
TBX21 T-box 21
TCOF1 Treacher Collins-Franceschetti syndrome 1
TGS1 trimethylguanosine synthase 1
THBD thrombomodulin
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR9 toll-like receptor 9
TNS3 tensin 3
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
TRAF3IP2 TRAF3 interacting protein 2
TRAF4 TNF receptor-associated factor 4
TRIO trio Rho guanine nucleotide exchange factor
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TUBA1A tubulin, alpha 1a
UHMK1 U2AF homology motif (UHM) kinase 1
UNC5C unc-5 homolog C (C. elegans)
UNC5D unc-5 homolog D (C. elegans)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIM vimentin
WAS Wiskott-Aldrich syndrome
WASL Wiskott-Aldrich syndrome-like
WDPCP WD repeat containing planar cell polarity effector
WDR1 WD repeat domain 1
WNT5A wingless-type MMTV integration site family, member 5A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18
ZEB2 zinc finger E-box binding homeobox 2
ZFAND5 zinc finger, AN1-type domain 5
ZYX zyxin