abnormal cell cycle Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description failure to progress or abnormal progression through the stages of the cell cycle (Mammalian Phenotype Ontology, MP_0003077)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003077
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Genes

212 gene mutations causing the abnormal cell cycle phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ATM ATM serine/threonine kinase
ATOH7 atonal homolog 7 (Drosophila)
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BRAP BRCA1 associated protein
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRD2 bromodomain containing 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CACYBP calcyclin binding protein
CBX7 chromobox homolog 7
CCNA2 cyclin A2
CCNF cyclin F
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CENPA centromere protein A
CENPC centromere protein C
CENPE centromere protein E, 312kDa
CENPJ centromere protein J
CHD2 chromodomain helicase DNA binding protein 2
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CIRBP cold inducible RNA binding protein
COMMD3-BMI1 COMMD3-BMI1 readthrough
COPS8 COP9 signalosome subunit 8
CSRP2BP CSRP2 binding protein
CTNND1 catenin (cadherin-associated protein), delta 1
CUL3 cullin 3
CUL4A cullin 4A
CUX2 cut-like homeobox 2
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DIAPH3 diaphanous-related formin 3
DICER1 dicer 1, ribonuclease type III
DIDO1 death inducer-obliterator 1
DNA2 DNA replication helicase/nuclease 2
DPH1 diphthamide biosynthesis 1
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
E4F1 E4F transcription factor 1
EDNRB endothelin receptor type B
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EGR1 early growth response 1
EIF6 eukaryotic translation initiation factor 6
EN1 engrailed homeobox 1
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2
EYA1 EYA transcriptional coactivator and phosphatase 1
FANCC Fanconi anemia, complementation group C
FANCM Fanconi anemia, complementation group M
FBXO5 F-box protein 5
FIGN fidgetin
FNTB farnesyltransferase, CAAX box, beta
FOXK1 forkhead box K1
FOXM1 forkhead box M1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GFI1 growth factor independent 1 transcription repressor
GIGYF2 GRB10 interacting GYF protein 2
GLRX3 glutaredoxin 3
GMNN geminin, DNA replication inhibitor
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPX1 glutathione peroxidase 1
H3F3A H3 histone, family 3A
HAT1 histone acetyltransferase 1
HDAC1 histone deacetylase 1
HDAC3 histone deacetylase 3
HIPK2 homeodomain interacting protein kinase 2
HLA-DOA major histocompatibility complex, class II, DO alpha
HMGN1 high mobility group nucleosome binding domain 1
HSPB1 heat shock 27kDa protein 1
HUS1 HUS1 checkpoint homolog (S. pombe)
IFT122 intraflagellar transport 122
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
ING1 inhibitor of growth family, member 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JDP2 Jun dimerization protein 2
JUND jun D proto-oncogene
KAT8 K(lysine) acetyltransferase 8
KDM5A lysine (K)-specific demethylase 5A
KIF18A kinesin family member 18A
KIF20B kinesin family member 20B
LATS1 large tumor suppressor kinase 1
LATS2 large tumor suppressor kinase 2
LIG3 ligase III, DNA, ATP-dependent
LMNA lamin A/C
LZTS1 leucine zipper, putative tumor suppressor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MASTL microtubule associated serine/threonine kinase-like
MBD4 methyl-CpG binding domain protein 4
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM9 minichromosome maintenance complex component 9
MCPH1 microcephalin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED1 mediator complex subunit 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIS18A MIS18 kinetochore protein A
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
NEK7 NIMA-related kinase 7
NFYA nuclear transcription factor Y, alpha
NONO non-POU domain containing, octamer-binding
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUPR1 nuclear protein, transcriptional regulator, 1
NUSAP1 nucleolar and spindle associated protein 1
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX3 paired box 3
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PHACTR4 phosphatase and actin regulator 4
PIFO primary cilia formation
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLK3 polo-like kinase 3
PLK4 polo-like kinase 4
PLRG1 pleiotropic regulator 1
POLB polymerase (DNA directed), beta
PPP4C protein phosphatase 4, catalytic subunit
PPP5C protein phosphatase 5, catalytic subunit
PRDX1 peroxiredoxin 1
PRICKLE1 prickle homolog 1 (Drosophila)
PRIMPOL primase and polymerase (DNA-directed)
PRMT2 protein arginine methyltransferase 2
PRMT6 protein arginine methyltransferase 6
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTTG1 pituitary tumor-transforming 1
RAE1 ribonucleic acid export 1
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBX1 ring-box 1, E3 ubiquitin protein ligase
RECQL RecQ helicase-like
RECQL5 RecQ protein-like 5
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGPD1 RANBP2-like and GRIP domain containing 1
RIF1 replication timing regulatory factor 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF7 ring finger protein 7
RPL24 ribosomal protein L24
RPL29 ribosomal protein L29
RPS6 ribosomal protein S6
RTEL1 regulator of telomere elongation helicase 1
SETD7 SET domain containing (lysine methyltransferase) 7
SIN3B SIN3 transcription regulator family member B
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SP2 Sp2 transcription factor
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPI1 Spi-1 proto-oncogene
STAG1 stromal antigen 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK11 serine/threonine kinase 11
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
SYF2 SYF2 pre-mRNA-splicing factor
TACC3 transforming, acidic coiled-coil containing protein 3
TADA3 transcriptional adaptor 3
TDP2 tyrosyl-DNA phosphodiesterase 2
TGIF1 TGFB-induced factor homeobox 1
TGS1 trimethylguanosine synthase 1
TMOD3 tropomodulin 3 (ubiquitous)
TMPO thymopoietin
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
TPP2 tripeptidyl peptidase II
TPX2 TPX2, microtubule-associated
TRIM28 tripartite motif containing 28
TSG101 tumor susceptibility 101
TSPYL2 TSPY-like 2
TTYH1 tweety family member 1
TUBG1 tubulin, gamma 1
TYK2 tyrosine kinase 2
UBA3 ubiquitin-like modifier activating enzyme 3
UBC ubiquitin C
UHMK1 U2AF homology motif (UHM) kinase 1
UIMC1 ubiquitin interaction motif containing 1
USP44 ubiquitin specific peptidase 44
VPRBP Vpr (HIV-1) binding protein
WNT6 wingless-type MMTV integration site family, member 6
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF830 zinc finger protein 830