abnormal cd8-positive, alpha-beta t cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the subset of T lymphocytes that express the CD8 marker on the cell surface (Mammalian Phenotype Ontology, MP_0004392)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004392
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Genes

86 gene mutations causing the abnormal cd8-positive, alpha-beta t cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
B2M beta-2-microglobulin
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBC3 BCL2 binding component 3
BCL10 B-cell CLL/lymphoma 10
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
CARD11 caspase recruitment domain family, member 11
CD226 CD226 molecule
CD27 CD27 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD7 CD7 molecule
CD70 CD70 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CHRM1 cholinergic receptor, muscarinic 1
CTSC cathepsin C
EBAG9 estrogen receptor binding site associated, antigen, 9
ELF4 E74-like factor 4 (ets domain transcription factor)
ERAP1 endoplasmic reticulum aminopeptidase 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FOXP3 forkhead box P3
G6PC2 glucose-6-phosphatase, catalytic, 2
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAVCR2 hepatitis A virus cellular receptor 2
HLA-G major histocompatibility complex, class I, G
HSH2D hematopoietic SH2 domain containing
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IL12B interleukin 12B
IL15 interleukin 15
IL2 interleukin 2
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL6 interleukin 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF8 interferon regulatory factor 8
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITK IL2-inducible T-cell kinase
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LY75 lymphocyte antigen 75
LYST lysosomal trafficking regulator
MBTPS1 membrane-bound transcription factor peptidase, site 1
MCL1 myeloid cell leukemia 1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PNLIPRP2 pancreatic lipase-related protein 2
PNP purine nucleoside phosphorylase
PRF1 perforin 1 (pore forming protein)
PRKD2 protein kinase D2
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB27A RAB27A, member RAS oncogene family
RABGGTA Rab geranylgeranyltransferase, alpha subunit
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH2D1A SH2 domain containing 1A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
STX11 syntaxin 11
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOX thymocyte selection-associated high mobility group box
TPP2 tripeptidyl peptidase II
UNC13D unc-13 homolog D (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
XCL1 chemokine (C motif) ligand 1
XCR1 chemokine (C motif) receptor 1