abnormal cd8-positive, alpha beta t cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions (Mammalian Phenotype Ontology, MP_0005010)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005010
Similar Terms
Downloads & Tools

Genes

227 gene mutations causing the abnormal cd8-positive, alpha beta t cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACP2 acid phosphatase 2, lysosomal
ADRM1 adhesion regulating molecule 1
AKAP9 A kinase (PRKA) anchor protein 9
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL4D ADP-ribosylation factor-like 4D
ATM ATM serine/threonine kinase
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BBC3 BCL2 binding component 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6B B-cell CLL/lymphoma 6, member B
BCLAF1 BCL2-associated transcription factor 1
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
BMF Bcl2 modifying factor
BTK Bruton agammaglobulinemia tyrosine kinase
CADM1 cell adhesion molecule 1
CARD11 caspase recruitment domain family, member 11
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD19 CD19 molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD70 CD70 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
CD8B CD8b molecule
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPJ centromere protein J
CHD7 chromodomain helicase DNA binding protein 7
CIITA class II, major histocompatibility complex, transactivator
CLEC10A C-type lectin domain family 10, member A
CLEC4G C-type lectin domain family 4, member G
CORO1A coronin, actin binding protein, 1A
CRTAM cytotoxic and regulatory T cell molecule
CTSV cathepsin V
CXCL10 chemokine (C-X-C motif) ligand 10
CYLD cylindromatosis (turban tumor syndrome)
CYTIP cytohesin 1 interacting protein
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DGKZ diacylglycerol kinase, zeta
DIAPH1 diaphanous-related formin 1
DLL1 delta-like 1 (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
E2F1 E2F transcription factor 1
EBAG9 estrogen receptor binding site associated, antigen, 9
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM83G family with sequence similarity 83, member G
FAS Fas cell surface death receptor
FBXO7 F-box protein 7
FOXN1 forkhead box N1
FOXP2 forkhead box P2
FOXP3 forkhead box P3
G6PC2 glucose-6-phosphatase, catalytic, 2
GCLC glutamate-cysteine ligase, catalytic subunit
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GPER1 G protein-coupled estrogen receptor 1
GPR15 G protein-coupled receptor 15
GRAP2 GRB2-related adaptor protein 2
HAVCR1 hepatitis A virus cellular receptor 1
HAX1 HCLS1 associated protein X-1
HCST hematopoietic cell signal transducer
HELLS helicase, lymphoid-specific
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-A major histocompatibility complex, class I, A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-G major histocompatibility complex, class I, G
HMGN5 high mobility group nucleosome binding domain 5
HP1BP3 heterochromatin protein 1, binding protein 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL2 interleukin 2
IL23A interleukin 23, alpha subunit p19
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
IRF1 interferon regulatory factor 1
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JAK3 Janus kinase 3
KAZN kazrin, periplakin interacting protein
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
LAG3 lymphocyte-activation gene 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIG4 ligase IV, DNA, ATP-dependent
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
LY75 lymphocyte antigen 75
MAVS mitochondrial antiviral signaling protein
MCL1 myeloid cell leukemia 1
MMP19 matrix metallopeptidase 19
MPZL2 myelin protein zero-like 2
MSI2 musashi RNA-binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NCR1 natural cytotoxicity triggering receptor 1
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC5 NLR family, CARD domain containing 5
NPY1R neuropeptide Y receptor Y1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAX1 paired box 1
PBX1 pre-B-cell leukemia homeobox 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PIGR polymeric immunoglobulin receptor
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PITX3 paired-like homeodomain 3
PLA2G10 phospholipase A2, group X
PNP purine nucleoside phosphorylase
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP5C protein phosphatase 5, catalytic subunit
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT3 protein arginine methyltransferase 3
PRSS50 protease, serine, 50
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASA3 RAS p21 protein activator 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBBP7 retinoblastoma binding protein 7
RGS3 regulator of G-protein signaling 3
RHOH ras homolog family member H
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RRAS related RAS viral (r-ras) oncogene homolog
RUNX3 runt-related transcription factor 3
RUVBL2 RuvB-like AAA ATPase 2
S1PR1 sphingosine-1-phosphate receptor 1
SASH3 SAM and SH3 domain containing 3
SATB1 SATB homeobox 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SETD1A SET domain containing 1A
SGMS1 sphingomyelin synthase 1
SGPL1 sphingosine-1-phosphate lyase 1
SH2D1A SH2 domain containing 1A
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIRT1 sirtuin 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC39A3 solute carrier family 39 (zinc transporter), member 3
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SPI1 Spi-1 proto-oncogene
SPNS2 spinster homolog 2 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYK spleen tyrosine kinase
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TBX21 T-box 21
TCF12 transcription factor 12
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TESPA1 thymocyte expressed, positive selection associated 1
THEMIS thymocyte selection associated
TICAM1 toll-like receptor adaptor molecule 1
TMEM127 transmembrane protein 127
TMEM189 transmembrane protein 189
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOM1L2 target of myb1-like 2 (chicken)
TOX thymocyte selection-associated high mobility group box
TPP2 tripeptidyl peptidase II
TRIB2 tribbles pseudokinase 2
TXNIP thioredoxin interacting protein
UNC13D unc-13 homolog D (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZBTB7B zinc finger and BTB domain containing 7B
ZEB1 zinc finger E-box binding homeobox 1
ZNF335 zinc finger protein 335