abnormal cd4-positive t cell differentiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production (Mammalian Phenotype Ontology, MP_0008076)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008076
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Genes

51 gene mutations causing the abnormal cd4-positive t cell differentiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BATF basic leucine zipper transcription factor, ATF-like
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
C3AR1 complement component 3a receptor 1
CARD11 caspase recruitment domain family, member 11
CD1D CD1d molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD83 CD83 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CISH cytokine inducible SH2-containing protein
CLEC6A C-type lectin domain family 6, member A
DOCK2 dedicator of cytokinesis 2
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
ICOSLG inducible T-cell co-stimulator ligand
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IL13 interleukin 13
IL17RA interleukin 17 receptor A
IL2 interleukin 2
IL21R interleukin 21 receptor
IL23R interleukin 23 receptor
IL27 interleukin 27
IL4 interleukin 4
IRF4 interferon regulatory factor 4
LCK LCK proto-oncogene, Src family tyrosine kinase
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
NCKAP1L NCK-associated protein 1-like
PCSK1 proprotein convertase subtilisin/kexin type 1
PGAP3 post-GPI attachment to proteins 3
PRKCQ protein kinase C, theta
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFTN1 raftlin, lipid raft linker 1
RSAD2 radical S-adenosyl methionine domain containing 2
SASH3 SAM and SH3 domain containing 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SIT1 signaling threshold regulating transmembrane adaptor 1
SMAD3 SMAD family member 3
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TBX21 T-box 21
TOX thymocyte selection-associated high mobility group box
TSLP thymic stromal lymphopoietin
UNC93B1 unc-93 homolog B1 (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
ZBTB7B zinc finger and BTB domain containing 7B
ZNF335 zinc finger protein 335