abnormal cd4-positive, alpha-beta t cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production (Mammalian Phenotype Ontology, MP_0005463)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005463
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Genes

141 gene mutations causing the abnormal cd4-positive, alpha-beta t cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR4 atypical chemokine receptor 4
AHNAK AHNAK nucleoprotein
AIRE autoimmune regulator
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
C3AR1 complement component 3a receptor 1
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CBX5 chromobox homolog 5
CCR6 chemokine (C-C motif) receptor 6
CCRL2 chemokine (C-C motif) receptor-like 2
CD22 CD22 molecule
CD247 CD247 molecule
CD27 CD27 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD4 CD4 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD69 CD69 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CD83 CD83 molecule
CD84 CD84 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIITA class II, major histocompatibility complex, transactivator
CRTAM cytotoxic and regulatory T cell molecule
CXCR2 chemokine (C-X-C motif) receptor 2
ECM1 extracellular matrix protein 1
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLT3LG fms-related tyrosine kinase 3 ligand
FOXP3 forkhead box P3
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GPR84 G protein-coupled receptor 84
HAVCR1 hepatitis A virus cellular receptor 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-E major histocompatibility complex, class I, E
HSH2D hematopoietic SH2 domain containing
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IER3 immediate early response 3
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHM immunoglobulin heavy constant mu
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1RL1 interleukin 1 receptor-like 1
IL2 interleukin 2
IL20RB interleukin 20 receptor beta
IL21 interleukin 21
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL27RA interleukin 27 receptor, alpha
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
IL7R interleukin 7 receptor
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF5 interferon regulatory factor 5
JUND jun D proto-oncogene
LAT linker for activation of T cells
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK14 mitogen-activated protein kinase 14
MIR155 microRNA 155
MMP3 matrix metallopeptidase 3
MOG myelin oligodendrocyte glycoprotein
MPZ myelin protein zero
NDFIP1 Nedd4 family interacting protein 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP10 NLR family, pyrin domain containing 10
NME2 NME/NM23 nucleoside diphosphate kinase 2
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
PAWR PRKC, apoptosis, WT1, regulator
PCGF2 polycomb group ring finger 2
PDLIM2 PDZ and LIM domain 2 (mystique)
PGAP3 post-GPI attachment to proteins 3
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLXNA1 plexin A1
POU2AF1 POU class 2 associating factor 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTX3 pentraxin 3, long
RAD50 RAD50 homolog (S. cerevisiae)
RAG2 recombination activating gene 2
RC3H1 ring finger and CCCH-type domains 1
RCAN1 regulator of calcineurin 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS16 regulator of G-protein signaling 16
RHOG ras homolog family member G
RIPK2 receptor-interacting serine-threonine kinase 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SH2D1A SH2 domain containing 1A
SKAP1 src kinase associated phosphoprotein 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLAMF6 SLAM family member 6
SPHK2 sphingosine kinase 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBX21 T-box 21
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TRIM27 tripartite motif containing 27
TSLP thymic stromal lymphopoietin
TYK2 tyrosine kinase 2
VAV1 vav 1 guanine nucleotide exchange factor
ZBTB46 zinc finger and BTB domain containing 46
ZBTB7B zinc finger and BTB domain containing 7B