|Dataset||MPO Gene-Phenotype Associations|
|Category||disease or phenotype associations|
|Description||any structural anomaly of the branched acinotubular glands found in the submucosa of the duodenum located above the Sphincter of Oddi; their main function is to produce a mucus-rich alkaline secretion (containing bicarbonate) to protect the duodenum from the acidic content of chyme, provide an alkaline condition for the intestinal enzymes to be active (thus enabling absorption to take place), and lubricate the intestinal walls; they also secrete urogastrone, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes (Mammalian Phenotype Ontology, MP_0012518)|
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2 gene mutations causing the abnormal brunner's gland morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.