abnormal bone marrow cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased or decreased number of cells that make up the core cavities of bones when compared to controls (Mammalian Phenotype Ontology, MP_0000172)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000172
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Genes

127 gene mutations causing the abnormal bone marrow cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAR adenosine deaminase, RNA-specific
ALOX15 arachidonate 15-lipoxygenase
AR androgen receptor
ARHGAP1 Rho GTPase activating protein 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATF4 activating transcription factor 4
ATR ATR serine/threonine kinase
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRCA2 breast cancer 2, early onset
BTK Bruton agammaglobulinemia tyrosine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCND3 cyclin D3
CCNE1 cyclin E1
CD151 CD151 molecule (Raph blood group)
CD47 CD47 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CNN2 calponin 2
COMMD3-BMI1 COMMD3-BMI1 readthrough
CREBBP CREB binding protein
CSF1 colony stimulating factor 1 (macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DCC DCC netrin 1 receptor
DIAPH1 diaphanous-related formin 1
DKC1 dyskeratosis congenita 1, dyskerin
DST dystonin
EBF1 early B-cell factor 1
EGR1 early growth response 1
ELAVL1 ELAV like RNA binding protein 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRA estrogen-related receptor alpha
FANCC Fanconi anemia, complementation group C
FES FES proto-oncogene, tyrosine kinase
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
GAB2 GRB2-associated binding protein 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GJA1 gap junction protein, alpha 1, 43kDa
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
HAX1 HCLS1 associated protein X-1
HIP1 huntingtin interacting protein 1
HOXA9 homeobox A9
HOXB4 homeobox B4
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFNGR1 interferon gamma receptor 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2 interleukin 2
IL31RA interleukin 31 receptor A
IL7 interleukin 7
IL7R interleukin 7 receptor
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF8 interferon regulatory factor 8
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK2 Janus kinase 2
JAM2 junctional adhesion molecule 2
KAT6A K(lysine) acetyltransferase 6A
KIAA0101 KIAA0101
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LCN2 lipocalin 2
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEIS1 Meis homeobox 1
MPZL3 myelin protein zero-like 3
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOR2 nuclear receptor corepressor 2
NDFIP1 Nedd4 family interacting protein 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLK nemo-like kinase
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PBX1 pre-B-cell leukemia homeobox 1
PFDN1 prefoldin subunit 1
PGM3 phosphoglucomutase 3
PICALM phosphatidylinositol binding clathrin assembly protein
PRF1 perforin 1 (pore forming protein)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCH2 patched 2
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAD50 RAD50 homolog (S. cerevisiae)
RAG2 recombination activating gene 2
RASA3 RAS p21 protein activator 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBL1 retinoblastoma-like 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPL27A ribosomal protein L27a
RUNX2 runt-related transcription factor 2
SAMD9L sterile alpha motif domain containing 9-like
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SH2B3 SH2B adaptor protein 3
SHARPIN SHANK-associated RH domain interactor
SIPA1 signal-induced proliferation-associated 1
SIRT6 sirtuin 6
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SMAP1 small ArfGAP 1
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SPTA1 spectrin, alpha, erythrocytic 1
SYK spleen tyrosine kinase
TAL1 T-cell acute lymphocytic leukemia 1
TET2 tet methylcytosine dioxygenase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TP53 tumor protein p53
TRAT1 T cell receptor associated transmembrane adaptor 1
UROS uroporphyrinogen III synthase
USP1 ubiquitin specific peptidase 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM1 zinc finger protein, FOG family member 1