abnormal body fat mass Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant fat-containing physical bulk or volume of the body (Mammalian Phenotype Ontology, MP_0012320)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012320
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Genes

375 gene mutations causing the abnormal body fat mass phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY3 adenylate cyclase 3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA1B adrenoceptor alpha 1B
ADRB3 adrenoceptor beta 3
ADRM1 adhesion regulating molecule 1
AEBP1 AE binding protein 1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCYL1 adenosylhomocysteinase-like 1
AHNAK AHNAK nucleoprotein
AKAP9 A kinase (PRKA) anchor protein 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ALMS1 Alstrom syndrome protein 1
ALPL alkaline phosphatase, liver/bone/kidney
AMACR alpha-methylacyl-CoA racemase
AMER1 APC membrane recruitment protein 1
ANGPTL2 angiopoietin-like 2
ANGPTL4 angiopoietin-like 4
ANGPTL6 angiopoietin-like 6
APOE apolipoprotein E
AR androgen receptor
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARID5B AT rich interactive domain 5B (MRF1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARRDC3 arrestin domain containing 3
ARSB arylsulfatase B
ASIP agouti signaling protein
ASPA aspartoacylase
ATN1 atrophin 1
ATRN attractin
B9D1 B9 protein domain 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BBS1 Bardet-Biedl syndrome 1
BBS4 Bardet-Biedl syndrome 4
BBS5 Bardet-Biedl syndrome 5
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BCKDK branched chain ketoacid dehydrogenase kinase
BGLAP bone gamma-carboxyglutamate (gla) protein
BRD2 bromodomain containing 2
BRS3 bombesin-like receptor 3
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BSX brain-specific homeobox
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C3 complement component 3
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CARTPT CART prepropeptide
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CCDC80 coiled-coil domain containing 80
CCL13 chemokine (C-C motif) ligand 13
CCL25 chemokine (C-C motif) ligand 25
CD14 CD14 molecule
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDH23 cadherin-related 23
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CEP19 centrosomal protein 19kDa
CERS6 ceramide synthase 6
CHAD chondroadherin
CHD7 chromodomain helicase DNA binding protein 7
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CISD2 CDGSH iron sulfur domain 2
CLOCK clock circadian regulator
CLPS colipase, pancreatic
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CREB3L1 cAMP responsive element binding protein 3-like 1
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRHR2 corticotropin releasing hormone receptor 2
CRTC3 CREB regulated transcription coactivator 3
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTF1 cardiotrophin 1
CUL7 cullin 7
CUX1 cut-like homeobox 1
CYB5R4 cytochrome b5 reductase 4
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DBN1 drebrin 1
DDIT3 DNA-damage-inducible transcript 3
DDR2 discoidin domain receptor tyrosine kinase 2
DFNB31 deafness, autosomal recessive 31
DGAT1 diacylglycerol O-acyltransferase 1
DKC1 dyskeratosis congenita 1, dyskerin
DLG2 discs, large homolog 2 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DLL1 delta-like 1 (Drosophila)
DMXL2 Dmx-like 2
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNASE1L2 deoxyribonuclease I-like 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPT dermatopontin
DRD3 dopamine receptor D3
DSG1 desmoglein 1
DSG3 desmoglein 3
DUOX2 dual oxidase 2
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
E2F1 E2F transcription factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4H eukaryotic translation initiation factor 4H
EIF6 eukaryotic translation initiation factor 6
ELMOD1 ELMO/CED-12 domain containing 1
ERCC2 excision repair cross-complementation group 2
ERP44 endoplasmic reticulum protein 44
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRA estrogen-related receptor alpha
ESYT3 extended synaptotagmin-like protein 3
FAM134C family with sequence similarity 134, member C
FBXO11 F-box protein 11
FECH ferrochelatase
FFAR4 free fatty acid receptor 4
FGF10 fibroblast growth factor 10
FGF21 fibroblast growth factor 21
FOXO1 forkhead box O1
FTO fat mass and obesity associated
GAMT guanidinoacetate N-methyltransferase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCGR glucagon receptor
GDF15 growth differentiation factor 15
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GHSR growth hormone secretagogue receptor
GLP1R glucagon-like peptide 1 receptor
GNAS GNAS complex locus
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPM6A glycoprotein M6A
GPR12 G protein-coupled receptor 12
GPR21 G protein-coupled receptor 21
GPR22 G protein-coupled receptor 22
GPR26 G protein-coupled receptor 26
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPR39 G protein-coupled receptor 39
GPR50 G protein-coupled receptor 50
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRM5 glutamate receptor, metabotropic 5
GRM8 glutamate receptor, metabotropic 8
GSK3A glycogen synthase kinase 3 alpha
GTF2IRD1 GTF2I repeat domain containing 1
GUCY2C guanylate cyclase 2C
HADH hydroxyacyl-CoA dehydrogenase
HEXB hexosaminidase B (beta polypeptide)
HMGA2 high mobility group AT-hook 2
HRH1 histamine receptor H1
HRH3 histamine receptor H3
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTRA2 HtrA serine peptidase 2
IDUA iduronidase, alpha-L-
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KAT6B K(lysine) acetyltransferase 6B
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KIAA1549L KIAA1549-like
KLF15 Kruppel-like factor 15
KLF3 Kruppel-like factor 3 (basic)
KMT2B lysine (K)-specific methyltransferase 2B
KMT2E lysine (K)-specific methyltransferase 2E
KPTN kaptin (actin binding protein)
KSR2 kinase suppressor of ras 2
LCLAT1 lysocardiolipin acyltransferase 1
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LEPROT leptin receptor overlapping transcript
LGALS12 lectin, galactoside-binding, soluble, 12
LGI1 leucine-rich, glioma inactivated 1
LIN28A lin-28 homolog A (C. elegans)
LMNA lamin A/C
LPAR1 lysophosphatidic acid receptor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRN3 leucine rich repeat neuronal 3
LTBP1 latent transforming growth factor beta binding protein 1
MAPK8 mitogen-activated protein kinase 8
MARC2 mitochondrial amidoxime reducing component 2
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MBOAT4 membrane bound O-acyltransferase domain containing 4
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
MCM2 minichromosome maintenance complex component 2
MECOM MDS1 and EVI1 complex locus
MFSD2A major facilitator superfamily domain containing 2A
MIR378A microRNA 378a
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MOGAT2 monoacylglycerol O-acyltransferase 2
MPI mannose phosphate isomerase
MRAP2 melanocortin 2 receptor accessory protein 2
MSTN myostatin
MTA1 metastasis associated 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBPC3 myosin binding protein C, cardiac
MYO6 myosin VI
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NEB nebulin
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NHLH2 nescient helix loop helix 2
NMUR2 neuromedin U receptor 2
NOX3 NADPH oxidase 3
NPTN neuroplastin
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NR2E1 nuclear receptor subfamily 2, group E, member 1
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NTS neurotensin
NXN nucleoredoxin
OPA1 optic atrophy 1 (autosomal dominant)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OPRM1 opioid receptor, mu 1
OSTM1 osteopetrosis associated transmembrane protein 1
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PAM peptidylglycine alpha-amidating monooxygenase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PDE3B phosphodiesterase 3B, cGMP-inhibited
PFN1 profilin 1
PGF placental growth factor
PHEX phosphate regulating endopeptidase homolog, X-linked
PHF2 PHD finger protein 2
PHIP pleckstrin homology domain interacting protein
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PITX3 paired-like homeodomain 3
PKNOX1 PBX/knotted 1 homeobox 1
PLAU plasminogen activator, urokinase
PLIN1 perilipin 1
PLIN2 perilipin 2
PNLIP pancreatic lipase
PNRC2 proline-rich nuclear receptor coactivator 2
POLG polymerase (DNA directed), gamma
POMC proopiomelanocortin
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PRDM4 PR domain containing 4
PREP prolyl endopeptidase
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCDBP protein kinase C, delta binding protein
PRKCE protein kinase C, epsilon
PRLHR prolactin releasing hormone receptor
PROX1 prospero homeobox 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTHLH parathyroid hormone-like hormone
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYY peptide YY
RAB6B RAB6B, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBL1 retinoblastoma-like 1
RDH16 retinol dehydrogenase 16 (all-trans)
RGN regucalcin
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RLN3 relaxin 3
RNF10 ring finger protein 10
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPGRIP1L RPGRIP1-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RSC1A1 regulatory solute carrier protein, family 1, member 1
RUNX3 runt-related transcription factor 3
RYR1 ryanodine receptor 1 (skeletal)
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SDC3 syndecan 3
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SIM1 single-minded family bHLH transcription factor 1
SIRT3 sirtuin 3
SIRT6 sirtuin 6
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC25A30 solute carrier family 25, member 30
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A7 solute carrier family 30 (zinc transporter), member 7
SLC38A10 solute carrier family 38, member 10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SMCO2 single-pass membrane protein with coiled-coil domains 2
SNAP47 synaptosomal-associated protein, 47kDa
SNRPN small nuclear ribonucleoprotein polypeptide N
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOX8 SRY (sex determining region Y)-box 8
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPTB spectrin, beta, erythrocytic
SRA1 steroid receptor RNA activator 1
STAG1 stromal antigen 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STAT5B signal transducer and activator of transcription 5B
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERF2IP telomeric repeat binding factor 2, interacting protein
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THRA thyroid hormone receptor, alpha
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TMEM189 transmembrane protein 189
TMEM27 transmembrane protein 27
TMUB1 transmembrane and ubiquitin-like domain containing 1
TNF tumor necrosis factor
TNIK TRAF2 and NCK interacting kinase
TOM1L2 target of myb1-like 2 (chicken)
TPGS1 tubulin polyglutamylase complex subunit 1
TRIB1 tribbles pseudokinase 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TSN translin
TTLL4 tubulin tyrosine ligase-like family member 4
TUB tubby bipartite transcription factor
TWIST2 twist family bHLH transcription factor 2
UBB ubiquitin B
UBE3B ubiquitin protein ligase E3B
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UMOD uromodulin
UNC79 unc-79 homolog (C. elegans)
USH1C Usher syndrome 1C (autosomal recessive, severe)
USP38 ubiquitin specific peptidase 38
VGF VGF nerve growth factor inducible
VIPR2 vasoactive intestinal peptide receptor 2
XDH xanthine dehydrogenase
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
XYLB xylulokinase homolog (H. influenzae)
ZEB1 zinc finger E-box binding homeobox 1
ZFAND5 zinc finger, AN1-type domain 5