abnormal behavioral response to xenobiotic Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior (Mammalian Phenotype Ontology, MP_0009745)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009745
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Genes

227 gene mutations causing the abnormal behavioral response to xenobiotic phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADCY5 adenylate cyclase 5
ADGRL3 adhesion G protein-coupled receptor L3
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADORA2A adenosine A2a receptor
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKAP5 A kinase (PRKA) anchor protein 5
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMPH amphiphysin
AP3M2 adaptor-related protein complex 3, mu 2 subunit
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
AQP4 aquaporin 4
ARX aristaless related homeobox
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
AVPR1B arginine vasopressin receptor 1B
BHLHE40 basic helix-loop-helix family, member e40
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3
BSN bassoon presynaptic cytomatrix protein
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CALCB calcitonin-related polypeptide beta
CCKBR cholecystokinin B receptor
CCL13 chemokine (C-C motif) ligand 13
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD81 CD81 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRM2 cholinergic receptor, muscarinic 2
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CIT citron rho-interacting serine/threonine kinase
CKB creatine kinase, brain
CLCN3 chloride channel, voltage-sensitive 3
CLN3 ceroid-lipofuscinosis, neuronal 3
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNTN2 contactin 2 (axonal)
CREB1 cAMP responsive element binding protein 1
CRHR1 corticotropin releasing hormone receptor 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAO D-amino-acid oxidase
DLG4 discs, large homolog 4 (Drosophila)
DLGAP3 discs, large (Drosophila) homolog-associated protein 3
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
EFHC1 EF-hand domain (C-terminal) containing 1
EPS8 epidermal growth factor receptor pathway substrate 8
FAAH fatty acid amide hydrolase
FAIM2 Fas apoptotic inhibitory molecule 2
FGF14 fibroblast growth factor 14
FGF22 fibroblast growth factor 22
FGF7 fibroblast growth factor 7
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD9 frizzled class receptor 9
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAL galanin/GMAP prepropeptide
GDI1 GDP dissociation inhibitor 1
GFAP glial fibrillary acidic protein
GLRA1 glycine receptor, alpha 1
GLRA3 glycine receptor, alpha 3
GNAS GNAS complex locus
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR26 G protein-coupled receptor 26
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRK6 G protein-coupled receptor kinase 6
GRM2 glutamate receptor, metabotropic 2
GRM5 glutamate receptor, metabotropic 5
GRM7 glutamate receptor, metabotropic 7
GSTM5 glutathione S-transferase mu 5
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCRTR1 hypocretin (orexin) receptor 1
HIPK2 homeodomain interacting protein kinase 2
HLTF helicase-like transcription factor
HOMER1 homer scaffolding protein 1
HOMER2 homer scaffolding protein 2
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IL6 interleukin 6
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
JUN jun proto-oncogene
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK8 kallikrein-related peptidase 8
LGI1 leucine-rich, glioma inactivated 1
LHX6 LIM homeobox 6
LMO4 LIM domain only 4
LRRK2 leucine-rich repeat kinase 2
LYST lysosomal trafficking regulator
MAPK10 mitogen-activated protein kinase 10
MAPT microtubule-associated protein tau
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCHR1 melanin-concentrating hormone receptor 1
MECP2 methyl CpG binding protein 2
MGLL monoglyceride lipase
MT3 metallothionein 3
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NEUROD2 neuronal differentiation 2
NIPBL Nipped-B homolog (Drosophila)
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NPAS3 neuronal PAS domain protein 3
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRP2 neuropilin 2
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PANX1 pannexin 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE11A phosphodiesterase 11A
PDE8A phosphodiesterase 8A
PDLIM5 PDZ and LIM domain 5
PDYN prodynorphin
PENK proenkephalin
PER2 period circadian clock 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCL1 phospholipase C-like 1
PNOC prepronociceptin
POMC proopiomelanocortin
POR P450 (cytochrome) oxidoreductase
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRICKLE2 prickle homolog 2 (Drosophila)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCG protein kinase C, gamma
PRLHR prolactin releasing hormone receptor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RGS4 regulator of G-protein signaling 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
S100A10 S100 calcium binding protein A10
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN2B sodium channel, voltage gated, type II beta subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SEZ6 seizure related 6 homolog (mouse)
SH3KBP1 SH3-domain kinase binding protein 1
SLC10A4 solute carrier family 10, member 4
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SLITRK5 SLIT and NTRK-like family, member 5
SOD1 superoxide dismutase 1, soluble
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SYNGAP1 synaptic Ras GTPase activating protein 1
SZT2 seizure threshold 2 homolog (mouse)
TAAR1 trace amine associated receptor 1
TACR1 tachykinin receptor 1
TAOK2 TAO kinase 2
TRIM3 tripartite motif containing 3
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UNC79 unc-79 homolog (C. elegans)
UPP1 uridine phosphorylase 1
WFS1 Wolfram syndrome 1 (wolframin)